Invest Ophthalmol Vis SciSeptember 202010 citations

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position.

Omoto Takashi, Murata Hiroshi, Fujino Yuri, Matsuura Masato, Fujishiro Takashi, Hirasawa Kazunori, Yamashita Takehiro, Kanamoto Takashi, Miki Atsuya, Ikeda Yoko

View on PubMed DOI: 10.1167/iovs.61.11.16

AI Summary

This study found that narrower retinal artery angles, indicating more ocular elongation, correlated with significantly thinner macular ganglion cell layers, highlighting a potential structural impact of myopia.

Abstract

Purpose

We recently reported on the usefulness of retinal artery trajectory in estimating the magnitude of retinal stretch due to myopia. The purpose of the present study was to elucidate the relationship between the peripapillary retinal artery angle (PRAA) and thickness of the macular ganglion cell-inner plexiform layer (GCIPL).

Methods

This r included 138 healthy eyes of 79 subjects older than 20 years of age without any known eye disease. GCIPL thickness was separated into eight sectors according to quadrant and eccentricity from the fovea. The PRAA was calculated as the angle between the superior and inferior retinal arteries. Relationships between whole GCIPL thickness (average and sectorial) and the values of PRAA and axial length (AL) were investigated using a linear mixed model.

Results

Average GCIPL thickness in the whole scanned area decreased significantly with narrowing of the PRAA with and without adjusting for AL. Sectorized macular GCIPL thickness also decreased significantly, with narrowing of the PRAA in seven out of the eight with the adjustment of AL, the exception being the inferior peripheral temporal sector.

Conclusions

Macular GCIPL thickness decreased significantly with narrowing of the PRAA on average and in seven out of eight sectors.

MeSH Terms

AdultFemaleHumansMaleMyopiaNerve FibersOptic DiskRetinal ArteryRetinal Ganglion CellsTomography, Optical CoherenceVisual FieldsYoung Adult

Shields Classification

Ch. 4Optic Nerve, Retina, and Choroid

Key Concepts2

Average macular ganglion cell-inner plexiform layer (GCIPL) thickness in the whole scanned area decreased significantly with narrowing of the peripapillary retinal artery angle (PRAA) with and without adjusting for axial length (AL) in 138 healthy eyes of 79 subjects.

PrognosisCross-sectionalCross-sectional studyn=138 healthy eyes of 79 subjectsCh5

Sectorized macular ganglion cell-inner plexiform layer (GCIPL) thickness decreased significantly with narrowing of the peripapillary retinal artery angle (PRAA) in seven out of the eight sectors, with the adjustment of axial length (AL), in 138 healthy eyes of 79 subjects.