Choroidal Microvasculature Dropout is Associated with Generalized Choroidal Vessel Loss within the β-Parapapillary Atrophy in Glaucoma.
Jo Youn Hye, Shin Joong Won, Song Min Kyung, Won Hun Jae, Kook Michael S
AI Summary
This study found glaucoma eyes with choroidal microvasculature dropout (MvD) also have widespread choroidal vessel loss around the optic nerve, indicating MvD signals broader vascular insufficiency.
Abstract
Purpose
To determine whether eyes with open-angle glaucoma (OAG) and a localized choroidal microvasculature dropout (MvD) are associated with a greater degree of generalized choroidal vascular insufficiency within the β-parapapillary atrophy (β-PPA) than OAG eyes without MvD.
Design
Retrospective cross-sectional study.
Methods
This study included 100 OAG eyes with visual field (VF) loss confined to a single hemifield (50 with and 50 without MvD, matched for age [≤10 years ols], axial length [≤1 mm], and VF severity [≤1 dB]), as well as 50 healthy eyes. Using optical coherence tomography angiography, parapapillary choroidal vessel density (pCVD) was measured on en-face images of choroidal maps within the entire β-PPA after excluding the MvD area and hemi-sectors of the β-PPA. pCVDs were compared among the 3 groups. The relationships between pCVD outcomes and various clinical variables were assessed. Logistical regression analyses were performed to determine the clinical factors associated with the presence of MvD in eyes with OAG.
Results
pCVDs corresponding to the VF-intact hemi-sectors and the entire β-PPA, excluding the MvD area, were significantly lower in eyes with MvD than in matched sectors of eyes without MvD. Multivariate linear regression analysis showed that the presence of MvD and greater MvD angular extent were independently associated with lower global pCVD in OAG eyes (all P < .05). Logistic regression analyses showed that lower pCVD was the only factor significantly associated with the presence of MvD.
Conclusions
Localized MvD was a strong predictor of generalized pCVD loss within the β-PPA in OAG eyes.
MeSH Terms
Shields Classification
Key Concepts4
Parapapillary choroidal vessel densities (pCVDs) corresponding to the visual field-intact hemi-sectors and the entire β-parapapillary atrophy (β-PPA), excluding the microvasculature dropout (MvD) area, were significantly lower in eyes with MvD than in matched sectors of open-angle glaucoma (OAG) eyes without MvD.
Multivariate linear regression analysis showed that the presence of microvasculature dropout (MvD) and greater MvD angular extent were independently associated with lower global parapapillary choroidal vessel density (pCVD) in open-angle glaucoma (OAG) eyes (all P < .05).
Logistic regression analyses showed that lower parapapillary choroidal vessel density (pCVD) was the only factor significantly associated with the presence of microvasculature dropout (MvD) in open-angle glaucoma (OAG) eyes.
Localized microvasculature dropout (MvD) was a strong predictor of generalized parapapillary choroidal vessel density (pCVD) loss within the β-parapapillary atrophy (β-PPA) in open-angle glaucoma (OAG) eyes.
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