BLOOD CHROMIUM-COBALT LEVELS IN PATIENTS AFTER TOTAL KNEE ARTHROPLASTY AND THEIR EFFECT ON THE RETINAL NERVE FIBER LAYER AND MACULAR GANGLION CELL COMPLEX.
Oğurel Tevfik, Serbest Sancar, Oğurel Reyhan, Tiftikçi Uğur, Ölmez Yaşar
AI Summary
Total knee arthroplasty patients had elevated blood cobalt/chromium, which was associated with thinner retinal nerve fiber layer and macular ganglion cell complex, suggesting potential ocular toxicity.
Abstract
Purpose
To study blood cobalt (Co) and chromium (Cr) levels in patients who have undergone total knee arthroplasty and their effect on the retinal nerve fiber layer and macular ganglion cell complex.
Methods
One hundred patients who had undergone total knee arthroplasty and 50 healthy individuals who had no implants were included in the study. The patients were separated into two groups based on how long ago the prosthesis had been implanted (Group 1: 1 to 5 years; Group 2: 5 to 10 years). After a complete ophthalmological examination, retinal nerve fiber layer and macular ganglion cell complex of the patients were evaluated with optical coherence tomography, performed on dilated pupils. To assess the metal ion levels of the patients, venous blood samples were drawn from each patient.
Results
The mean age of the patients was 64.72 ± 6.26 years in Group 1, 67.80 ± 8.07 years in Group 2, and 63.42 ± 7.90 years in the control group. In the comparison of age and sex, there were no statistically significant differences between the groups and the control group. Co and Cr levels were statistically higher in Group 1 and Group 2 compared with the control group (P < 0.001). Mean retinal nerve fiber layer thicknesses and mean macular ganglion cell complex thicknesses in Group 1 and Group 2 were statistically lower than in the control group.
Conclusion
Levels of Co and Cr are higher in patients who undergone total knee arthroplasty than healthy subjects, and these higher levels were associated with changes in the retinal nerve fiber layer and macular ganglion cell complex.
MeSH Terms
Shields Classification
Key Concepts5
Blood cobalt (Co) and chromium (Cr) levels were statistically higher in patients who had undergone total knee arthroplasty (Group 1: 1 to 5 years post-arthroplasty; Group 2: 5 to 10 years post-arthroplasty) compared with healthy individuals who had no implants (P < 0.001).
Mean retinal nerve fiber layer thicknesses were statistically lower in patients who had undergone total knee arthroplasty (Group 1: 1 to 5 years post-arthroplasty; Group 2: 5 to 10 years post-arthroplasty) compared to healthy individuals who had no implants.
Mean macular ganglion cell complex thicknesses were statistically lower in patients who had undergone total knee arthroplasty (Group 1: 1 to 5 years post-arthroplasty; Group 2: 5 to 10 years post-arthroplasty) compared to healthy individuals who had no implants.
Higher levels of cobalt and chromium in patients who had undergone total knee arthroplasty were associated with changes in the retinal nerve fiber layer and macular ganglion cell complex.
A cross-sectional study included 100 patients who had undergone total knee arthroplasty, separated into two groups based on prosthesis implantation time (Group 1: 1 to 5 years; Group 2: 5 to 10 years), and 50 healthy individuals as a control group.
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