Diagnostic performance of wide-field optical coherence tomography angiography in detecting open-angle glaucoma in high myopia.
Zhang Yinhang, Wang Deming, Lin Fengbin, Song Yunhe, Chen Yu, Peng Yuying, Chen Meiling, Liu Yuhong, Jiang Jiaxuan, Yang Zefeng
AI Summary
Wide-field OCTA showed central 1-6mm retinal capillary density best detects glaucoma in high myopia. More peripheral regions offered no additional diagnostic value for these patients.
Abstract
Purpose
To compare the diagnostic performance of the capillary density (CD) of the central 1-6 mm and peripheral 6-12 mm annular regions in detecting open-angle glaucoma in high myopia (HM) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
Methods
The study enrolled 206 and 103 eyes with HM and highly myopic open-angle glaucoma (HM-OAG), respectively. WF SS-OCTA images centred on the fovea were obtained to analyse the changes in the CD in the 1-3 mm, 3-6 mm, 6-9 mm, and 9-12 mm annular regions. CD of the superficial capillary plexus (SCP) was measured with the built-in software. The area under the receiver operating characteristic curve (AUROC) of each region was compared.
Results
The diagnostic performance of the SCP CD in the central 1-6 mm annular region (AUROC = 0.849) was better than that in the peripheral 6-12 mm annular region (AUROC = 0.756, p = 0.001). The annular AUROCs of SCP CD peaked in the 3-6 mm annular region (AUROC = 0.858) and gradually decreased with increasing diameter and were lower than the corresponding AUROCs of the ganglion cell-inner plexiform layer thickness (p < 0.05 for all comparisons). SCP CD of the inferior quadrant in the 3-6 mm annular region had the best diagnostic performance (AUROC = 0.859).
Conclusion
The SCP CD in the central 1-6 mm annular region exhibited better diagnostic performance for the detection of HM-OAG in HM. The assessment of more peripheral regions has no added value in detecting glaucoma in HM.
MeSH Terms
Shields Classification
Key Concepts5
The diagnostic performance of the superficial capillary plexus (SCP) capillary density (CD) in the central 1-6 mm annular region (AUROC = 0.849) was better than that in the peripheral 6-12 mm annular region (AUROC = 0.756, p = 0.001) for detecting open-angle glaucoma in high myopia (HM-OAG) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
The annular AUROCs of superficial capillary plexus (SCP) capillary density (CD) peaked in the 3-6 mm annular region (AUROC = 0.858) and gradually decreased with increasing diameter for detecting open-angle glaucoma in high myopia (HM-OAG) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
The annular AUROCs of superficial capillary plexus (SCP) capillary density (CD) were lower than the corresponding AUROCs of the ganglion cell-inner plexiform layer thickness (p < 0.05 for all comparisons) for detecting open-angle glaucoma in high myopia (HM-OAG) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
Superficial capillary plexus (SCP) capillary density (CD) of the inferior quadrant in the 3-6 mm annular region had the best diagnostic performance (AUROC = 0.859) for detecting open-angle glaucoma in high myopia (HM-OAG) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
The assessment of more peripheral regions of superficial capillary plexus (SCP) capillary density has no added value in detecting glaucoma in high myopia (HM) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
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