Clinical Significance of Recurrent Disc Hemorrhage and Choroidal Microvasculature Dropout on Optical Coherence Tomography Angiography in Glaucoma.
Oh Si Eun, Shin Hee Jong, Park Chan Kee, Park Hae-Young Lopilly
AI Summary
Recurrent disc hemorrhage with microvasculature dropout signals higher central visual field progression, necessitating closer follow-up and aggressive treatment to prevent vision loss.
Abstract
Purpose
The purpose of this study was to investigate the clinical significance of recurrent disc hemorrhage (DH) and choroidal microvasculature dropout (MvD).
Methods
A retrospective cohort study was conducted of 181 eyes with open-angle glaucoma. The clinical characteristics of patients with nonrecurrent and recurrent DH with and without MvD were investigated.
Results
Fifty-eight patients (32.0%) had a single, nonrecurrent DH, and 63 (34.8%) had more than one DH. Sixty eyes (33.1%) with no history of DH were presented as a control group. MvD was more frequent in the recurrent DH group (44.4%) than in the nonrecurrent DH group (27.6%, P = 0.041). The recurrent DH with MvD group experienced more frequent central visual field (VF) progression (71.4%) than the recurrent DH without MvD group (17.1 %, P < 0.001). The recurrent DH without MvD group had a higher frequency of DH recurrence at different locations (42.9%) and more vascular symptoms (37.1%) than the recurrent DH with MvD group (14.3% and 7.1%, P = 0.013 and P = 0.005, respectively). Presence of DH, presence of MvD, vascular symptoms, and DH recurrence at different locations were the factors associated with central VF progression in multivariate analysis.
Conclusions
DH occurrence and the presence of MvDs constitute critical parameters associated with central VF progression. In the presence of MvD, recurrent DH was more likely to recur at the same location as the MvD, whereas recurrent DH without MvD was related to vascular symptoms and recurred at other locations. When eyes present with recurrent DH and MvD, closer follow-up and more aggressive treatment are required to prevent the progression of central VF.
MeSH Terms
Shields Classification
Key Concepts5
Choroidal microvasculature dropout (MvD) was more frequent in the recurrent disc hemorrhage (DH) group (44.4%) than in the nonrecurrent DH group (27.6%, P = 0.041) in a retrospective cohort study of 181 eyes with open-angle glaucoma.
The recurrent disc hemorrhage (DH) with choroidal microvasculature dropout (MvD) group experienced more frequent central visual field (VF) progression (71.4%) than the recurrent DH without MvD group (17.1 %, P < 0.001) in a retrospective cohort study of 181 eyes with open-angle glaucoma.
The recurrent disc hemorrhage (DH) without choroidal microvasculature dropout (MvD) group had a higher frequency of DH recurrence at different locations (42.9%) and more vascular symptoms (37.1%) than the recurrent DH with MvD group (14.3% and 7.1%, P = 0.013 and P = 0.005, respectively) in a retrospective cohort study of 181 eyes with open-angle glaucoma.
Presence of disc hemorrhage (DH), presence of choroidal microvasculature dropout (MvD), vascular symptoms, and DH recurrence at different locations were factors associated with central visual field (VF) progression in multivariate analysis in a retrospective cohort study of 181 eyes with open-angle glaucoma.
When eyes present with recurrent disc hemorrhage (DH) and choroidal microvasculature dropout (MvD), closer follow-up and more aggressive treatment are required to prevent the progression of central visual field (VF) based on findings from a retrospective cohort study of 181 eyes with open-angle glaucoma.
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