Evaluating the Usefulness of MP-3 Microperimetry in Glaucoma Patients.

PURPOSE

The purpose of the current study was to evaluate the test-retest reproducibility and structure-function relationship of the MP-3 microperimeter, compared against the Humphrey Field Analyzer (HFA).

METHODS

Design: Reliability and validity study.

SETTING

Institutional, or clinical practice.

STUDY POPULATION

Thirty eyes of 30 primary open-angle glaucoma patients were enrolled.

OBSERVATION PROCEDURES

Visual fields (VF) were measured twice with the MP-3 and HFA instruments, using the 10-2 test grid pattern in both perimeters. Ganglion cell complex (GCC) thickness was measured using optical coherence tomography (OCT). Test-retest reproducibility was assessed using the mean absolute deviation (MAD) measure at all 68 VF test points, and also the intraclass correlation coefficient (ICC) of the repeated VF sensitivities. The structure-function relationship between VF sensitivities (measured with MP-3 or HFA) and GCC thickness (adjusted for the retinal ganglion cell displacement) was analyzed using linear mixed modeling.

MAIN OUTCOME MEASURE

Reproducibility and structure-function relationship.

RESULTS

The average measurement duration with the HFA 10-2 was 7 minutes and 6 seconds (7m06s) ± 0m49s (mean ± standard deviation). A significantly (P < .001, paired Wilcoxon test) longer measurement duration was observed for the MP-3 test: 10m29s ± 2m55s. There were no significant differences in MAD and ICC values between HFA (MAD; 0.83 ± 0.69 dB and

ICC

0.89 ± 0.69, mean ± standard deviation) and MP-3 (MAD: 0.65 ± 0.67 dB and

ICC

0.89 ± 0.69). MP-3 VF sensitivities had a stronger structure-function relationship with GCC thickness compared to HFA.

CONCLUSIONS

The MP-3 microperimeter has a similar test-retest reproducibility to the HFA but a better structure-function relationship.