Comparative Analysis of 10-2 Test on Advanced Vision Analyzer and Humphrey Perimeter in Glaucoma.

PURPOSE

To evaluate diagnostic precision and prove equivalence of 2 devices, Advanced vision analyzer (AVA, Elisar Vision Technology) and Humphrey field analyzer (HFA, Zeiss) for the detection of glaucoma on 10-2 program.

DESIGN

Prospective, cross-sectional, observational study.

PARTICIPANTS

Threshold estimates of 1 eye each of 66 patients with glaucoma, 36 control participants, and 10 glaucoma suspects were analyzed on 10-2 test with AVA and HFA.

METHODS

Mean sensitivity (MS) values of 68 points and central 16 test points were calculated and compared. Intraclass correlation (ICC), Bland-Altman (BA) plots, linear regression of MS, mean deviation (MD), and pattern standard deviation (PSD) were computed to assess the 10-2 threshold estimate of the devices. Receiver operating characteristic curves were generated for MS and MD values, and the area under the curve (AUC) was compared with assessing diagnostic precision.

MAIN OUTCOME MEASURES

Mean sensitivity values of 68 points and central 16 points, AUC for MS and MD values, ICC values, BA plots, and linear-regression analysis.

RESULTS

Bland-Altman plot showed significant correlation for MS, MD, and PSD values for both devices. For MS, the overall ICC value was 0.96 ( 0.05). The AUC for MS values for AVA was 0.89 and for HFA was 0.92 ( = 0.188); whereas it was similar at 0.88 for MD values ( = 0.799). Advanced vision analyzer and HFA identically discriminated between healthy and patients with glaucoma ( 0.05).

CONCLUSIONS

Statistical results denote adequate equivalence between AVA and HFA because threshold estimates of AVA strongly correlate with HFA for 10-2 program.

FINANCIAL DISCLOSURES

Proprietary or commercial disclosure may be found after the references.