Translational neuroprotection research in glaucoma: a review of definitions and principles.
Casson Robert J, Chidlow Glyn, Ebneter Andreas, Wood John P M, Crowston Jonathan, Goldberg Ivan
AI Summary
This review defines neuroprotection terms for glaucoma, highlighting the need for clear definitions to translate new therapies from lab to clinic, as current IOP reduction isn't always sufficient.
Abstract
The maintenance of vision, through prevention and attenuation of neuronal injury in glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular pressure is the only proven method to achieve these goals. Although this strategy enjoys considerable success, some patients progress to blindness; hence, additional management options are highly desirable. Several terms describing treatment modalities of neuronal diseases with potential applicability to glaucoma are used in the literature, including neuroprotection, neurorecovery, neurorescue and neuroregeneration. These phenomena have not been defined within a coherent framework. Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic.
MeSH Terms
Shields Classification
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