Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography.
Moghimi Sasan, Mazloumi Mehdi, Johari MohammadKarim, Abdi Parisa, Fakhraie Ghasem, Mohammadi Massood, Zarei Reza, Eslami Yadollah, Fard Masoud A, Lin Shan C
AI Summary
This study found that non-glaucomatous pseudoexfoliation syndrome patients have significantly thinner and peripherally displaced lamina cribrosa, suggesting a pre-glaucomatous structural vulnerability.
Abstract
Purpose
To evaluate the lamina cribrosa (LC) and peripapillary choroid in patients with pseudoexfoliation syndrome (PXS).
Methods
In this cross-sectional study, one eye each of 32 nonglaucomatous PXS cases and 29 healthy volunteers were enrolled. The optic discs were scanned using enhanced depth imaging spectral-domain optical coherence tomography, and measurements were obtained using HEYEX software 6.0. LC and other related variables at three areas (mid-superior, center, and mid-inferior) and peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust the variables.
Results
After adjustment for age, sex, and axial length, there was no significant difference between the two groups in peripapillary choroidal thickness or in retinal nerve fiber layer thickness. The LC was significantly thinner in all three areas in the PXS group when compared with the control group, even after adjustment. Although no significant difference in central laminar depth was observed between the two groups (P = 0.74), the superior and inferior laminar depth were significantly deeper in the PXS group when compared with the control group (P = 0.04 and P = 0.006, respectively). Although there was a significant negative association between age and central choroidal thickness in the control group (β = -2.820, P = 0.02), this correlation was not significant in the PXS group.
Conclusions
We found that LC is significantly thinner in all three areas of the optic nerve head in nonglaucomatous PXS patients than in controls. Although no significant difference in peripapillary choroidal thickness was observed between the two groups, peripheral posterior displacement of LC in nonglaucomatous PXS eyes was noted.
MeSH Terms
Shields Classification
Key Concepts4
The lamina cribrosa (LC) was significantly thinner in all three areas (mid-superior, center, and mid-inferior) in nonglaucomatous pseudoexfoliation syndrome (PXS) patients when compared with the control group, even after adjustment for age, sex, and axial length.
Superior and inferior laminar depth were significantly deeper in nonglaucomatous pseudoexfoliation syndrome (PXS) patients (P = 0.04 and P = 0.006, respectively) when compared to healthy controls, although no significant difference in central laminar depth was observed between the two groups (P = 0.74).
There was no significant difference in peripapillary choroidal thickness or retinal nerve fiber layer thickness between nonglaucomatous pseudoexfoliation syndrome (PXS) patients and healthy controls, after adjustment for age, sex, and axial length.
A significant negative association between age and central choroidal thickness was observed in the control group (β = -2.820, P = 0.02), but this correlation was not significant in the nonglaucomatous pseudoexfoliation syndrome (PXS) group.
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