Alvarado J A

Alvarado J A, Alvarado R G, Yeh R F, Franse-Carman L, Marcellino G R, Brownstein M J

Laser-activated trabecular meshwork cells release factors increasing Schlemm's canal permeability, suggesting a novel glaucoma mechanism and potential therapeutic targets for aqueous outflow regulation.

Alvarado J A, Murphy C G, Franse-Carman L, Chen J, Underwood J L

Beta-agonists increase fluid flow through outflow pathway cells by widening intercellular spaces, suggesting epinephrine lowers intraocular pressure by enhancing fluid drainage in glaucoma.

Francis B A, Cortes A, Chen J, Alvarado J A

This study found the Ahmed glaucoma implant acts as a valve, regulating pressure by adjusting resistance, while Optimed and Krupin implants behave like simple resistors, increasing pressure linearly with flow. This impacts surgical choice for consistent pressure control.

Chen J, Cohn R A, Lin S C, Cortes A E, Alvarado J A

Endoscopic cyclophotocoagulation (ECP) safely and effectively lowered intraocular pressure in refractory glaucoma patients, reducing medications with stable vision. This offers a valuable treatment option for difficult cases.

Shirato S, Murphy C G, Bloom E, Franse-Carman L, Maglio M T, Polansky J R et al.

This study characterized phagocytosis in human trabecular meshwork cells, finding a sigmoid-like uptake curve, significant cell changes, and maximum phagocytosis around 96 hours, which is relevant for understanding outflow resistance in glaucoma.

Yun A J, Murphy C G, Polansky J R, Newsome D A, Alvarado J A

HTM cells secrete most ECM proteins, but dexamethasone uniquely induced elastin production. This suggests a mechanism for steroid-induced glaucoma.

Perkins T W, Alvarado J A, Polansky J R, Stilwell L, Maglio M, Juster R

HTM cell monolayers on filters showed hydraulic conductivity mimicking outflow. Cytochalasin B dramatically increased conductivity by cell retraction, offering a model to study aqueous outflow regulation.

Weinreb R N, Polansky J R, Alvarado J A, Mitchell M D

HTM cells metabolize arachidonic acid into diverse eicosanoids (PGE2, PGF2α, HETEs, LTB4), suggesting complex roles in aqueous outflow regulation and potential therapeutic targets.

Shuman M A, Polansky J R, Merkel C, Alvarado J A

Human trabecular meshwork cells produce abundant t-PA, a clot-dissolving enzyme, with minimal inhibitor. This suggests fibrinolysis is crucial for maintaining outflow and preventing glaucoma.

Murphy C G, Yun A J, Newsome D A, Alvarado J A

Researchers mapped proteins in healthy human trabecular meshwork, finding a unique, complex extracellular matrix composition. This structure likely contributes to its compliance and resilience, critical for regulating eye fluid outflow.

Polansky J R, Wood I S, Maglio M T, Alvarado J A

Cultured human trabecular cells maintain key structural/functional properties, including phagocytosis and ECM production, crucial for understanding outflow pathway health and glaucoma pathology.

Alvarado J A, Wood I, Polansky J R

This study characterized cultured human trabecular cells, finding they retain key features of in-vivo cells, offering a valuable model to understand glaucoma's cellular basis.