Alward W L

Ahram D F, Alward W L, Kuehn M H

This review found PACG has genetic factors influencing risk and endophenotypes, highlighting genetics' role in this common, heritable glaucoma.

Kawase C, Kawase K, Taniguchi T, Sugiyama K, Yamamoto T, Kitazawa Y et al.

This study found four FOXC1 mutations, two novel, in four of six Japanese Axenfeld-Rieger syndrome families, confirming this gene's role in anterior segment maldevelopment and variable glaucoma severity.

Kwon Y H, Kim C S, Zimmerman M B, Alward W L, Hayreh S S

This study found primary open-angle glaucoma causes slow visual field loss (-1.5%/year) with standard therapy. Lower IOP and more medications correlate with slower decline, but 19% risk legal blindness over 22 years.

Kwon Y H, Taylor J M, Hong S, Honkanen R A, Zimmerman M B, Alward W L et al.

This study found glaucoma tubes effectively control pressure in most corneal transplant eyes (82% at 3 years), but corneal graft survival is poor (55% at 3 years), highlighting complex outcomes.

Fingert J H, Clark A F, Craig J E, Alward W L, Snibson G R, McLaughlin M et al.

This study found no significant link between MYOC gene variations and steroid-induced ocular hypertension in humans or monkeys, suggesting MYOC mutations aren't a primary cause of this condition.

Swiderski R E, Ross J L, Fingert J H, Clark A F, Alward W L, Stone E M et al.

MYOC gene expression was found in ocular outflow tissues and the optic nerve. This suggests myocilin's role in aqueous humor regulation and optic nerve health, potentially impacting glaucoma.

Kwon Y H, Hong S, Honkanen R A, Alward W L

This study correlated visual fields with nerve fiber layer thickness, finding a bilinear relationship with high variability. Correlation was better with significant visual field defects, making prediction difficult in early disease.

Alward W L

This review found Axenfeld-Rieger syndrome and related disorders, linked to specific genes (PITX2, FKHL7), are one condition with high glaucoma risk, simplifying classification for better patient care.

Alward W L

Studying juvenile glaucoma in a family revealed myocilin gene mutations (GLC1A) cause most juvenile and some adult open-angle glaucoma, impacting disease presentation and prevalence across populations.

Alward W L

Haynes W L, Alward W L

This study found combining autologous blood injection and bleb compression sutures effectively treated hypotony maculopathy after trabeculectomy, improving vision and stabilizing eye pressure.

Oh K T, Alward W L, Kardon R H

A Baerveldt glaucoma implant can cause myositis, potentially due to plate migration against an extraocular muscle. This highlights a rare but reversible complication requiring implant removal.

Haynes W L, Alward W L

This abstract discusses managing post-trabeculectomy IOP, emphasizing understanding and treating events like bleb failure, hypotony, and flat anterior chambers to maintain surgical success and optimize patient outcomes.

Alward W L

Alward W L, Fingert J H, Coote M A, Johnson A T, Lerner S F, Junqua D et al.

Researchers found various GLC1A gene mutations in 4.6% of glaucoma patients. These mutations are linked to a wide spectrum of glaucoma, from juvenile to late-onset, highlighting genetic influence on disease presentation.

Carlson D W, Alward W L, Barad J P, Zimmerman M B, Carney B L

This study found that intraoperative mitomycin C during combined cataract and glaucoma surgery significantly lowered IOP and reduced medication needs, improving surgical success.

Stone E M, Fingert J H, Alward W L, Nguyen T D, Polansky J R, Sunden S L et al.

Researchers identified a gene (TIGR) on chromosome 1q causing primary open-angle glaucoma. Mutations in TIGR were found in 3.9% of patients, aiding early diagnosis and treatment.

Alward W L, Johnson A T, Nishimura D Y, Sheffield V C, Stone E M

Carlson D W, Alward W L, Folberg R

A child's aggressive iris nevus, unusually located and invading the trabecular meshwork, caused secondary glaucoma, highlighting a rare, severe presentation.

Munden P M, Alward W L

This study found combined cataract and glaucoma surgery with mitomycin C effectively lowered eye pressure and improved vision in selected patients, proving safe and beneficial for coexisting conditions.

Haynes W L, Alward W L, McKinney J K

Hayreh S S, Zimmerman M B, Podhajsky P, Alward W L

This study found nocturnal hypotension, particularly diastolic, is significantly associated with visual field deterioration in optic nerve disorders like normal-tension glaucoma and AION, suggesting a critical role in their pathogenesis.

Ritch R, Alward W L

Joos K M, Alward W L, Folberg R

Endoscopic goniotomy in pig eyes allowed clear visualization and effective incision of angle structures despite cloudy corneas, suggesting a potential treatment for infantile glaucoma.

Johnson A T, Drack A V, Kwitek A E, Cannon R L, Stone E M, Alward W L

This study characterized a family with severe, early-onset autosomal dominant juvenile glaucoma, finding high penetrance and excluding the Rieger's syndrome locus, suggesting a novel glaucoma gene.