The genetic mechanisms of primary angle closure glaucoma.
Ahram D F, Alward W L, Kuehn M H
This review found PACG has genetic factors influencing risk and endophenotypes, highlighting genetics' role in this common, heritable glaucoma.
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29 articles in GJC
Ahram D F, Alward W L, Kuehn M H
This review found PACG has genetic factors influencing risk and endophenotypes, highlighting genetics' role in this common, heritable glaucoma.
Kawase C, Kawase K, Taniguchi T, Sugiyama K, Yamamoto T, Kitazawa Y et al.
This study found four FOXC1 mutations, two novel, in four of six Japanese Axenfeld-Rieger syndrome families, confirming this gene's role in anterior segment maldevelopment and variable glaucoma severity.
Kwon Y H, Kim C S, Zimmerman M B, Alward W L, Hayreh S S
This study found primary open-angle glaucoma causes slow visual field loss (-1.5%/year) with standard therapy. Lower IOP and more medications correlate with slower decline, but 19% risk legal blindness over 22 years.
Kwon Y H, Taylor J M, Hong S, Honkanen R A, Zimmerman M B, Alward W L et al.
This study found glaucoma tubes effectively control pressure in most corneal transplant eyes (82% at 3 years), but corneal graft survival is poor (55% at 3 years), highlighting complex outcomes.
Fingert J H, Clark A F, Craig J E, Alward W L, Snibson G R, McLaughlin M et al.
This study found no significant link between MYOC gene variations and steroid-induced ocular hypertension in humans or monkeys, suggesting MYOC mutations aren't a primary cause of this condition.
Swiderski R E, Ross J L, Fingert J H, Clark A F, Alward W L, Stone E M et al.
MYOC gene expression was found in ocular outflow tissues and the optic nerve. This suggests myocilin's role in aqueous humor regulation and optic nerve health, potentially impacting glaucoma.
Kwon Y H, Hong S, Honkanen R A, Alward W L
This study correlated visual fields with nerve fiber layer thickness, finding a bilinear relationship with high variability. Correlation was better with significant visual field defects, making prediction difficult in early disease.
Alward W L
This review found Axenfeld-Rieger syndrome and related disorders, linked to specific genes (PITX2, FKHL7), are one condition with high glaucoma risk, simplifying classification for better patient care.
Alward W L
Studying juvenile glaucoma in a family revealed myocilin gene mutations (GLC1A) cause most juvenile and some adult open-angle glaucoma, impacting disease presentation and prevalence across populations.
Alward W L
Haynes W L, Alward W L
This study found combining autologous blood injection and bleb compression sutures effectively treated hypotony maculopathy after trabeculectomy, improving vision and stabilizing eye pressure.
Oh K T, Alward W L, Kardon R H
A Baerveldt glaucoma implant can cause myositis, potentially due to plate migration against an extraocular muscle. This highlights a rare but reversible complication requiring implant removal.
Haynes W L, Alward W L
This abstract discusses managing post-trabeculectomy IOP, emphasizing understanding and treating events like bleb failure, hypotony, and flat anterior chambers to maintain surgical success and optimize patient outcomes.
Alward W L, Fingert J H, Coote M A, Johnson A T, Lerner S F, Junqua D et al.
Researchers found various GLC1A gene mutations in 4.6% of glaucoma patients. These mutations are linked to a wide spectrum of glaucoma, from juvenile to late-onset, highlighting genetic influence on disease presentation.
Carlson D W, Alward W L, Barad J P, Zimmerman M B, Carney B L
This study found that intraoperative mitomycin C during combined cataract and glaucoma surgery significantly lowered IOP and reduced medication needs, improving surgical success.
Stone E M, Fingert J H, Alward W L, Nguyen T D, Polansky J R, Sunden S L et al.
Researchers identified a gene (TIGR) on chromosome 1q causing primary open-angle glaucoma. Mutations in TIGR were found in 3.9% of patients, aiding early diagnosis and treatment.
Alward W L, Johnson A T, Nishimura D Y, Sheffield V C, Stone E M
Carlson D W, Alward W L, Folberg R
A child's aggressive iris nevus, unusually located and invading the trabecular meshwork, caused secondary glaucoma, highlighting a rare, severe presentation.
Munden P M, Alward W L
This study found combined cataract and glaucoma surgery with mitomycin C effectively lowered eye pressure and improved vision in selected patients, proving safe and beneficial for coexisting conditions.
Haynes W L, Alward W L, McKinney J K
Hayreh S S, Zimmerman M B, Podhajsky P, Alward W L
This study found nocturnal hypotension, particularly diastolic, is significantly associated with visual field deterioration in optic nerve disorders like normal-tension glaucoma and AION, suggesting a critical role in their pathogenesis.
Ritch R, Alward W L
Joos K M, Alward W L, Folberg R
Endoscopic goniotomy in pig eyes allowed clear visualization and effective incision of angle structures despite cloudy corneas, suggesting a potential treatment for infantile glaucoma.
Johnson A T, Drack A V, Kwitek A E, Cannon R L, Stone E M, Alward W L
This study characterized a family with severe, early-onset autosomal dominant juvenile glaucoma, finding high penetrance and excluding the Rieger's syndrome locus, suggesting a novel glaucoma gene.