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Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class.
Schrittwieser Johannes, Reitner Andreas, Kircher Karl, Bertich Martin, Stapf Christoph, Lilja Stephanie V et al.
Invest Ophthalmol Vis SciApr 20260 citationsCohort Study
OPA1 missense variants lead to worse vision and greater inner retinal thinning than haploinsufficiency. Macular GCL thickness and papillomacular bundle sensitivity are key clinical indicators for ADOA progression and severity.