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Effect of Pegcetacoplan on Aqueous Humor Proteome in Geographic Atrophy: A Prospective Exploration.
Trivizki Omer, Wykoff Charles C, Smoor Magda A, Rabinovitch David, Zhou Avery, Cao Jessica A et al.
Invest Ophthalmol Vis SciDec 20251 citationsClinical Trial
Pegcetacoplan for GA induces a global aqueous humor proteomic shift, increasing numerous complement proteins and altering inflammation/coagulation. This reveals complex downstream effects beyond C3 inhibition, warranting further study for clinical implications.