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The influence of intraocular pressure on the transscleral diffusion of high-molecular-weight compounds.
Cruysberg Lars P J, Nuijts Rudy M M A, Geroski Dayle H, Gilbert Jake A, Hendrikse Fred, Edelhauser Henry F
Invest Ophthalmol Vis SciOct 200522 citationsBasic Science
This study found that human scleral permeability to large molecules generally decreases with increasing intraocular pressure, but transscleral delivery of high-molecular-weight drugs remains feasible even at elevated pressures.