Downes Susan M

Yusuf Imran H, Han Ruofan C, Downes Susan M, Sharma Srilakshmi M

UK study found HCQ retinopathy incidence was low (0.04-0.08%), but monitoring coverage was very poor (2.6-5.5%). Monitoring preserved better vision, highlighting its clinical importance despite low uptake.

Yusuf Imran H, Han Ruofan C, Downes Susan M, Sharma Srilakshmi M

A UK survey found 24-43 new cases of hydroxychloroquine retinopathy annually. This low incidence suggests under-diagnosis, highlighting the critical need for regular monitoring to detect pre-symptomatic damage.

Ghanchi Faruque, Bourne Rupert, Downes Susan M, Gale Richard, Rennie Christina, Tapply Ian et al.

This review highlights novel long-acting therapies for chronic eye diseases like glaucoma, finding they reduce treatment burden and improve compliance, crucial for preserving vision.

Kuehlewein Laura, Zobor Ditta, Andreasson Sten Olof, Ayuso Carmen, Banfi Sandro, Bocquet Beatrice et al.

This study characterized PDE6A-associated retinitis pigmentosa, finding symmetrical, often mild-to-moderate visual impairment. This suggests a valuable "window of opportunity" for future gene therapy in affected patients.

Charbel Issa Peter, Gliem Martin, Yusuf Imran H, Birtel Johannes, Müller Philipp L, Mangold Elisabeth et al.

This study found the CDHR1 c.783G>A variant causes a specific macular dystrophy resembling central areolar choroidal dystrophy. This "silent" mutation leads to exon skipping, highlighting its importance in diagnosing macular degeneration.

Bellingrath Julia-Sophia, Ochakovski G Alex, Seitz Immanuel P, Kohl Susanne, Zrenner Eberhart, Hanig Nicola et al.

This study of RPGR-linked retinitis pigmentosa found high visual symmetry between eyes, supporting fellow-eye control in trials. Visual acuity and III4e visual fields are useful progression markers.