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(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a ฯR1-Dependent Mechanism.
Zhao Jing, Mysona Barbara A, Qureshi Azam, Kim Lily, Fields Taylor, Gonsalvez Graydon B et al.
Invest Ophthalmol Vis SciFeb 201628 citationsBasic Science
(+)-Pentazocine protected retinal ganglion cells from NMDA-induced death in mice via sigma-1 receptor activation. This suggests ฯR1 is a promising therapeutic target for neurodegenerative retinal diseases like glaucoma.