Goto Hiroshi

Utsumi Takuya, Noma Hidetaka, Yasuda Kanako, Goto Hiroshi, Shimura Masahiko

Ranibizumab for diabetic macular edema reduced aqueous VEGF, PlGF, PDGF-AA, and IP-10. Baseline levels of PlGF, MCP-1, and IL-6 correlated with visual improvement, suggesting these are therapeutic targets.

Terada Yukiko, Kaburaki Toshikatsu, Takase Hiroshi, Goto Hiroshi, Nakano Satoko, Inoue Yoshitsugu et al.

This study found distinct clinical features differentiate CMV anterior uveitis from HSV/VZV, with CMV showing insidious onset, small KPs, and higher glaucoma risk, guiding targeted diagnosis and management.

Usui Yoshihiko, Tsubota Kinya, Agawa Tsuyoshi, Ueda Shunichiro, Umazume Kazuhiko, Okunuki Yoko et al.

Aqueous humor levels of angiogenin, IL-8, and MCP-1 were significantly higher in malignant uveal melanoma. These mediators may help differentiate malignant from benign intraocular tumors, aiding diagnosis and management.

Naruo-Tsuchisaka Asako, Maruyama Katsuhiko, Arimoto Go, Goto Hiroshi

Trabeculectomy with mitomycin C causes postoperative ptosis in 19% of patients by 6 months, significantly reducing eyelid margin-reflex distance, a notable complication for patients.

Umazume Kazuhiko, Usui Yoshihiko, Wakabayashi Yoshihiro, Okunuki Yoko, Kezuka Takeshi, Goto Hiroshi

This study found elevated soluble CD14 and inflammatory cytokines in DME eyes, correlating with VEGF and worse visual acuity, suggesting sCD14 is a key inflammatory driver in DME.

Matsunaga Yoshimichi, Kezuka Takeshi, An Xiaoming, Fujita Kouji, Matsuyama Nagahisa, Matsuda Ryusaku et al.

This study found microglial activation precedes T-cell infiltration and demyelination in experimental optic neuritis, correlating with early visual decline. This helps understand disease progression and guides future treatment strategies.

Matsuda Ryusaku, Kezuka Takeshi, Nishiyama Chiharu, Usui Yoshihiko, Matsunaga Yoshimichi, Okunuki Yoko et al.

IL-10 gene-transfected dendritic cells suppressed experimental autoimmune optic neuritis in mice, reducing inflammation and disease severity. This suggests a potential therapeutic strategy for autoimmune optic neuropathies.

Wakabayashi Yoshihiro, Usui Yoshihiko, Okunuki Yoko, Ueda Shunichiro, Kimura Keisuke, Muramatsu Daisuke et al.

This study found high intraocular VEGF levels during vitrectomy for PDR predict early vitreous hemorrhage and neovascular glaucoma, identifying patients at higher risk for these complications.

Okunuki Yoko, Usui Yoshihiko, Katai Naomichi, Kezuka Takeshi, Takeuchi Masaru, Goto Hiroshi et al.

This study found higher intraocular VEGF and IL-8 levels correlate with better macular edema improvement after vitrectomy for BRVO, suggesting these factors predict surgical success.

Suzuki Jun, Goto Hiroshi, Komase Katsuhiro, Abo Hitoshi, Fujii Kaoru, Otsuki Noriyuki et al.

This study found rubella virus antibodies and genetic material in FHI patients, suggesting rubella is a key cause, impacting diagnosis and potentially future treatment strategies.

Takeuchi Masaru, Iwasaki Takuya, Kezuka Takeshi, Usui Yoshihiko, Okunuki Yoko, Sakai Jun-ichi et al.

This study found that visual acuity and retinal thickness decline with uveitis duration in Behçet's patients, but perimetric sensitivity is relatively preserved, highlighting distinct impacts of chronic inflammation.

Suzuki Jun, Goto Hiroshi, Usui Masahiko

A ciliary body tumor caused optic disc neovascularization and macular edema, likely via VEGF. Tumor removal resolved these complications, highlighting the need to consider such tumors in similar presentations.