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Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.
Ogata-Iwao Minako, Inatani Masaru, Iwao Keiichiro, Takihara Yuji, Nakaishi-Fukuchi Yuko, Irie Fumitoshi et al.
Invest Ophthalmol Vis SciAug 201128 citationsBasic Science
This study found Heparan sulfate is crucial for guiding RGC axons to the optic nerve, modulating Netrin-1 and Slit signaling. Its disruption causes severe axon misguidance, relevant for understanding developmental optic neuropathies.