Karanjia Rustum

He Ye, Karanjia Rustum, Zhang Xiaowei, Wanderer Daniel, Walker Evan, Lee Seung Hyen et al.

This study found intermittent upright posture effectively prevented optic disc edema in a spaceflight-SANS model, suggesting fluid shift reversal is key to preventing optic nerve damage.

Karanjia Rustum, Sadun Alfredo A

Topical elamipretide for LHON was well-tolerated but didn't significantly improve BCVA. However, post-hoc visual field improvements and open-label visual function gains suggest potential benefit warranting further study.

Mejia-Vergara Alvaro J, Sadun Alfredo A, Chen Alexander F, Smith Michael F, Wall Michael, Karanjia Rustum

Studying LHON patients, stimulus size V perimetry showed lower variability and better dynamic range than size III, making it a more reliable tool for monitoring disease progression and treatment response.

Asanad Samuel, Ross-Cisneros Fred N, Nassisi Marco, Barron Ernesto, Karanjia Rustum, Sadun Alfredo A

This study found significant thinning in both inner and outer retinal layers in Alzheimer's disease patients, providing a histopathologic basis for retinal changes observed clinically.

Karanjia Rustum, Berezovsky Adriana, Sacai Paula Yuri, Cavascan Nivea Nunes, Liu Henry Yuheng, Nazarali Samir et al.

This study found the PhNR, a measure of RGC function, is significantly reduced in LHON patients and carriers. This objective test could monitor disease and treatment efficacy, even subclinically.

Hwang Tiffany Jean, Karanjia Rustum, Moraes-Filho Milton Nunes, Gale Jesse, Tran Jeffrey Show, Chu Edward R et al.

This study found that LHON vision loss and retinal nerve fiber layer swelling begin months before clinical conversion, peaking at conversion and then declining, highlighting a slower, pre-symptomatic disease progression.