1.
Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.
Siggs Owen M, Han Xikun, Qassim Ayub, Souzeau Emmanuelle, Kuruvilla Shilpa, Marshall Henry N et al.
JAMA OphthalmolSep 202121 citationsCross-Sectional Study
This study compared monogenic and polygenic glaucoma risks, finding high polygenic risk is as significant as single-gene mutations, more common, and associated with similar diagnosis age, making it clinically important for risk stratification.