Lessell S

Levin L A, Gragoudas E S, Lessell S

Optic nerve radiation damage correlates with fewer endothelial cells, suggesting vascular injury underlies radiation optic neuropathy, highlighting the importance of radiation dose.

Bianchi-Marzoli S, Rizzo J F, Brancato R, Lessell S

This study found compressive optic neuropathy significantly increases optic disc cupping, an acquired feature distinct from glaucoma. This helps differentiate causes of optic nerve damage.

Rizzo J F, Lessell S

Optic nerve sheath fenestration can cause choroidal infarction, leading to unexpected visual field loss and delayed funduscopic changes, highlighting a rare but serious surgical complication.

Levin L A, Joseph M P, Rizzo J F, Lessell S

This study found optic canal decompression improved vision in 71% of blunt head trauma patients, with younger individuals showing better outcomes, suggesting age is a key factor for treatment and future research.

Rizzo J F, Lessell S

Two patients developed profound bilateral vision loss post-surgery due to posterior ischemic optic neuropathy, likely caused by intraoperative optic nerve infarction. This highlights the risk of vision loss from systemic factors during surgery.

Lessell S

Ethambutol in rats caused focal axonal swelling in optic nerves/chiasm in 16% of animals, suggesting a mechanism for ethambutol-induced optic neuropathy in humans.