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Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma.
Kocherlakota Sai, Nicol Alan, Locri Filippo, Stebbins Karin J, Lorrain Daniel S, Tribble James R et al.
Transl Vis Sci TechnolJan 20260 citationsBasic Science
LPAR1 antagonist PIPE-791 failed to protect retinal ganglion cells, normalize vasculature, or reduce neuroinflammation in a rat ocular hypertension model. Reduced LPAR1 expression suggests targeting LPAR1 alone may not be a viable glaucoma neuroprotection strategy.