Luna Coralia

Luna Coralia, Parker Megan, Challa Pratap, Gonzalez Pedro

Viral delivery of miR-146a to rat eyes safely and effectively lowered intraocular pressure long-term. This suggests a promising gene therapy approach for human glaucoma.

Hannon Bailey G, Luna Coralia, Feola Andrew J, Ritch Matthew D, Read A Thomas, Stinnett Sandra S et al.

Genipin-induced scleral stiffening in rats caused no sustained harm to visual function, retinal health, or RGCs, supporting its future study for treating eye diseases like glaucoma.

Li Guorong, Luna Coralia, Gonzalez Pedro

This study found miR-183 inhibits DNA repair and proliferation in human trabecular meshwork cells by targeting KIAA0101. This suggests miR-183 contributes to glaucoma-related cellular senescence.

Wu Jing, Li Guorong, Luna Coralia, Spasojevic Ivan, Epstein David L, Gonzalez Pedro

Trabecular meshwork cells produce extracellular adenosine, mainly via CD73, which is vital for regulating aqueous humor outflow. Disrupting this pathway decreases outflow, suggesting a glaucoma mechanism.

Luna Coralia, Li Guorong, Qiu Jianming, Epstein David L, Gonzalez Pedro

This study found TGFβ2 downregulates miR-29 in trabecular meshwork cells, increasing ECM. miR-29b also inhibits TGFβ1. This crosstalk is crucial for outflow pathway regulation and glaucoma pathogenesis.

Li Guorong, Luna Coralia, Qiu Jianming, Epstein David L, Gonzalez Pedro

MiR-204 in glaucoma's drainage cells (HTM) was studied, finding it increases cell death and oxidative damage while reducing inflammation and ER stress response. This suggests miR-204 critically influences HTM health, impacting glaucoma pathogenesis.

Li Guorong, Luna Coralia, Qiu Jianming, Epstein David L, Gonzalez Pedro

Studying senescent HTM cells, researchers found miR-146a upregulation reduced inflammation and improved cell function. This suggests miR-146a could protect the trabecular meshwork from age-related damage in glaucoma.

Luna Coralia, Li Guorong, Qiu Jianming, Challa Pratap, Epstein David L, Gonzalez Pedro

Studied how mechanical stress releases ATP in eye cells, finding it mobilizes arachidonic acid and protective PGE2. This suggests a mechanism for glaucoma and potential therapeutic targets.

Liton Paloma B, Lin Yizhi, Luna Coralia, Li Guorong, Gonzalez Pedro, Epstein David L

Chronic oxidative stress in TM cells impairs lysosomal function, leading to waste accumulation. This suggests oxidative stress contributes to age-related TM dysfunction and glaucoma.