McGuigan David B

2 articles in GJC

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells.

Charng Jason, Jacobson Samuel G, Heon Elise, Roman Alejandro J, McGuigan David B, Sheplock Rebecca et al.

Invest Ophthalmol Vis SciJun 201718 citationsObservational Study

Studying pupillary light reflex in severe photoreceptor blindness (LCA) showed a slow, attenuated response. This isolates melanopsin activity, providing a benchmark for assessing retinal ganglion cell function in future therapies.

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Automated Light- and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa: Filling a Need to Accommodate Multicenter Clinical Trials.

McGuigan David B, Roman Alejandro J, Cideciyan Artur V, Matsui Rodrigo, Gruzensky Michaela L, Sheplock Rebecca et al.

Invest Ophthalmol Vis SciJun 201636 citationsClinical Trial

This study developed an automated perimetry method to measure rod and cone function in inherited retinal degenerations. It found this practical approach closely matched existing methods, offering a convenient tool for clinical trials.

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McGuigan David B

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells.

Automated Light- and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa: Filling a Need to Accommodate Multicenter Clinical Trials.