Michaelides Michel

Laich Yannik, Georgiou Michalis, Fujinami Kaoru, Daich Varela Malena, Fujinami-Yokokawa Yu, Hashem Shaima Awadh et al.

This study analyzed Best vitelliform macular dystrophy (BVMD) with OCT and FAF, revealing diverse imaging phenotypes. Specific OCT features correlated with visual acuity, highlighting a slow, variable disease course, challenging therapeutic trial endpoint identification.

Daich Varela Malena, Sanders Villa Alejandro, Pontikos Nikolas, Crossland Michael D, Michaelides Michel

This review highlights wearable devices collecting visual data for retinal disease monitoring, finding they offer objective, ecologically valid patient-centered outcomes for research and clinical care.

Michaelides Michel, Besirli Cagri G, Yang Yesa, DE Guimaraes Thales A C, Wong Sui Chien, Huckfeldt Rachel M et al.

This gene therapy for XLRP-RPGR was safe, well-tolerated, and improved retinal sensitivity and functional vision, supporting further study.

Katta Mohamed, de Guimaraes Thales A C, Fujinami-Yokokawa Yu, Fujinami Kaoru, Georgiou Michalis, Mahroo Omar A et al.

This study of 122 CSNB patients found stable retinal structure and visual acuity over time, with specific genetic variants (NYX, TRPM1) linked to myopia, aiding prognosis.

Kumaran Neruban, Rubin Gary S, Kalitzeos Angelos, Fujinami Kaoru, Bainbridge James W B, Weleber Richard G et al.

This study found volumetric central 30° visual field sensitivity (V30) is a key metric for monitoring RPE65-LCA progression, with genotype influencing sensitivity loss, aiding prognosis.

Tee James J L, Yang Yesa, Kalitzeos Angelos, Webster Andrew, Bainbridge James, Weleber Richard G et al.

This study found good, but variable, interocular visual function symmetry and a 6% annual decline in RPGR-associated retinopathy, guiding clinical prognosis and future treatment trials.

Hull Sarah, Arno Gavin, Ku Cristy A, Ge Zhongqi, Waseem Naushin, Chandra Aman et al.

This study expanded Knobloch syndrome findings, revealing new features like pigment dispersion and glaucoma, cone-rod dysfunction, and normal neuroradiology in some, aiding early diagnosis and management.

Weleber Richard G, Michaelides Michel, Trzupek Karmen M, Stover Niamh B, Stone Edwin M

This study characterized RPE65-mutated SECORD, finding variable presentation, disc drusen, and, uniquely, improved retinal function over time. This aids diagnosis for gene therapy candidates.

Michaelides Michel, Foster Paul J

This study found primary angle-closure often co-occurs with retinal vein occlusion, especially CRVO/HRVO. Clinically, gonioscopy should be performed in all RVO patients to detect and manage angle-closure.