Moster Mark L

Yu-Wai-Man Patrick, Newman Nancy J, Biousse Valérie, Carelli Valerio, Moster Mark L, Vignal-Clermont Catherine et al.

Gene therapy for LHON (MT-ND4 variant) showed sustained bilateral visual improvement and good safety up to five years, offering promising long-term benefit for patients.

Vignal-Clermont Catherine, Yu-Wai-Man Patrick, Newman Nancy J, Carelli Valerio, Moster Mark L, Biousse Valerie et al.

Lenadogene nolparvovec gene therapy for LHON showed good long-term safety. Most ocular side effects were mild, manageable inflammation/IOP, resolving with topical steroids. Systemic tolerability was excellent.

Newman Nancy J, Yu-Wai-Man Patrick, Carelli Valerio, Moster Mark L, Biousse Valerie, Vignal-Clermont Catherine et al.

This gene therapy study for early LHON found no significant visual acuity difference between treated and sham eyes, suggesting limited direct benefit from the injection itself.

DeBusk Adam, Moster Mark L

Gene therapy for optic nerve diseases shows promise in animal studies for RGC neuroprotection and axon regeneration. Clinical trials for LHON demonstrate safety, offering potential future treatments for vision loss.

Moster Stephen J, Moster Mark L, Scannell Bryan Molly, Sergott Robert C

This study found early retinal ganglion cell and inner plexiform layer thinning strongly correlates with vision loss in LHON, highlighting a critical therapeutic window within 6 months of diagnosis.

Lee Michele D, Odel Jeffrey G, Rudich Danielle S, Ritch Robert, Moster Mark L

A man's bending-induced vision loss was due to microhyphema from recent bleb manipulation, highlighting intraocular causes for such symptoms, even with vascular risk factors.

Williams Alice L, Lackey John, Wizov Sheryl S, Chia Tao Ming Thomas, Gatla Srinivas, Moster Mark L et al.

This MRI study found glaucoma patients have widespread, complex brain structural changes, including some larger areas and others correlating with disease severity, suggesting brain involvement beyond the eye.

Ney Joshua J, Volpe Nicholas J, Liu Grant T, Balcer Laura J, Moster Mark L, Galetta Steven L

This study found functional visual loss is prevalent in IIH patients, often linked to psychiatric issues. Careful assessment is crucial before surgery.

Moster Marlene R, Moster Mark L