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Pharmacological Depletion of Retinal Mononuclear Phagocytes Is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy.
Okrent Smolar Avital L, Viswanath Rahul, Bomze Howard M, Hao Ying, Stinnett Sandra S, Gospe Sidney M
Invest Ophthalmol Vis SciFeb 20260 citationsBasic Science
Pexidartinib-mediated MNP depletion, especially combined with hypoxia, completely protected RGCs and restored myelination in mitochondrial optic neuropathy. This suggests targeting neuroinflammation via MNP depletion is a promising adjunctive therapy for conditions like LHON.