Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma.
Pan Zheng, Liu Ke, Jiang Bing, Dong Chuning
This study identified novel glaucoma susceptibility genes, AFAP1 and FMNL2, through cross-tissue analysis, suggesting FMNL2's role in aqueous humor outflow and offering new therapeutic targets.