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Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys.
Buie LaKisha K, Rasmussen Carol A, Porterfield Eric C, Ramgolam Vinod S, Choi Vivian W, Markovic-Plese Silva et al.
Invest Ophthalmol Vis SciAug 200983 citationsBasic Science
Self-complementary AAV safely delivered genes to the trabecular meshwork in rats and monkeys, providing long-term expression without adverse effects. This supports gene therapy development for glaucoma.