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Ross Ahmara G

5 articles in GJC

5 articles in GJC

1.

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact.

Kwok Alex, Chaqour Brahim, Khan Reas S, Aravand Puya, Dine Kimberly, Ross Ahmara G et al.

Transl Vis Sci TechnolSep 20241 citationsBasic Science

This study found resveratrol and SIRT1 overexpression protected retinal ganglion cells and vision in mice with indirect traumatic optic neuropathy. This suggests resveratrol could be a therapy for human traumatic optic neuropathy.

2.

Comparison of SNCG and NEFH Promoter-Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma.

O'Neill Nuala, Meng Miranda, Chaqour Brahim, Dine Kimberly, Sarabu Neha, Pham Jennifer C et al.

Transl Vis Sci TechnolAug 20244 citationsBasic Science

Researchers found that smaller NEFH and SNCG promoters equally drive neuroprotective gene delivery to retinal ganglion cells in a glaucoma mouse model, improving RGC survival and vision. This allows for packaging larger therapeutic genes.

3.

Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.

Meng Miranda, Chaqour Brahim, O'Neill Nuala, Dine Kimberly, Sarabu Neha, Ying Gui-Shuang et al.

Invest Ophthalmol Vis SciApr 20249 citationsBasic Science

This study compared Brn3a and RBPMS markers for counting retinal ganglion cells (RGCs). Both detect RGC loss in aging and optic neuropathy, but Brn3a offers more consistent manual counts, aiding glaucoma research.

4.

The sensitivity and specificity of retinal and choroidal folds to distinguish between mild papilloedema and pseudopapilledema.

Reggie Sara N, Avery Robert A, Bavinger James C, Jivraj Imran, Alfaro Cesar, Pistilli Maxwell et al.

Eye (Lond)Jan 202110 citationsCross-Sectional Study

OCT-detected retinal/choroidal folds were studied to differentiate mild papilledema from pseudopapilledema. Folds were common in papilledema but rare in pseudopapilledema, suggesting their presence indicates true papilledema.

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