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Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye.
Lu Wennan, Hu HuiLing, Sévigny Jean, Gabelt B'Ann T, Kaufman Paul L, Johnson Elaine C et al.
Invest Ophthalmol Vis SciMay 201551 citationsBasic Science
Chronic glaucoma models show sustained high extracellular ATP and altered purinergic signaling in the posterior eye. This suggests ATP plays a chronic role in glaucoma damage, offering new therapeutic targets.