Sakai Hiroshi

Mataki Naomi, Mishima Koichi, Araie Makoto, Iwase Aiko, Murata Hiroshi, Otani Shinichiro et al.

Gonioscopy and UBM show significant disagreement in diagnosing occludable angles, with UBM both under- and over-diagnosing. Discrepancies relate to multiple anterior/posterior chamber factors, indicating neither method alone fully assesses angle closure.

Uejyo Chiharu, Henzan Ichiko Medoruma, Nakamura Yuko, Ishikawa Shusaku, Sakai Hiroshi, Sawaguchi Shoichi et al.

Van Herick grading (VH) was studied against UBM for angle closure and plateau iris. VH ≤2 significantly correlated with UBM angle width and ciliary body configuration, suggesting its utility for screening these conditions.

Yousefi Siamak, Sakai Hiroshi, Murata Hiroshi, Fujino Yuri, Matsuura Masato, Garway-Heath David et al.

This study found POAG eyes lose superior visual field faster than inferior, unlike PACG eyes, suggesting different progression patterns for these glaucoma types.

Yousefi Siamak, Sakai Hiroshi, Murata Hiroshi, Fujino Yuri, Garway-Heath David, Weinreb Robert et al.

This study found primary open-angle glaucoma causes more pronounced superior visual field loss than primary angle-closure glaucoma, which can aid in differentiating these conditions clinically.

Sawaguchi Shoichi, Sakai Hiroshi, Iwase Aiko, Yamamoto Tetsuya, Abe Haruki, Tomita Goji et al.

This study found primary angle-closure glaucoma is highly prevalent (2.2%) in rural Japan, significantly exceeding urban rates, highlighting regional differences in this blinding condition.

Tsutsumi Tae, Tomidokoro Atsuo, Araie Makoto, Iwase Aiko, Sakai Hiroshi, Sawaguchi Shoichi

This study found that in healthy Japanese eyes, larger optic cup/disc ratios and thinner rim widths correlated with age, disc size, higher IOP, lower ocular perfusion pressure, and thinner corneas, suggesting these parameters indicate glaucoma vulnerability.

Henzan Ichiko Medoruma, Tomidokoro Atsuo, Uejo Chiharu, Sakai Hiroshi, Sawaguchi Shoichi, Iwase Aiko et al.

This study used UBM to compare peripheral anterior chamber configurations in primary angle closure/suspects versus open angles. Key finding: PAC/suspects have shallower anterior chambers, and specific UBM parameters under light are excellent diagnostic differentiators.

Henzan Ichiko Medoruma, Tomidokoro Atsuo, Uejo Chiharu, Sakai Hiroshi, Sawaguchi Shoichi, Iwase Aiko et al.

This UBM study characterized anterior ocular segment dimensions, finding age, gender, refraction, and IOP significantly correlate with peripheral anterior chamber depth, ciliary body position, and iris thickness, informing glaucoma risk.

Tomoyose Eriko, Higa Akiko, Sakai Hiroshi, Sawaguchi Shoichi, Iwase Aiko, Tomidokoro Atsuo et al.

This Japanese study found intraocular pressure (IOP) correlated with younger age, higher BMI, blood pressure, diabetes, and specific corneal/ocular biometric factors, helping identify those at risk for elevated IOP.

Higa Akiko, Sakai Hiroshi, Sawaguchi Shoichi, Iwase Aiko, Tomidokoro Atsuo, Amano Shiro et al.

This study found average corneal endothelial cell density in normal Japanese adults was 2943 cells/mm², decreasing with age, higher IOP, male sex, and outdoor work, informing corneal health assessment.

Sakai Hiroshi, Park Bum-Chan, Shen Xiang, Yue Beatrice Y J T

TAT fusion proteins efficiently delivered proteins like myocilin into trabecular meshwork cells and tissues, altering cell structure. This technology could be valuable for studying glaucoma-related protein functions in the TM.

Sakai Hiroshi, Morine-Shinjyo Sayo, Shinzato Manabu, Nakamura Yoshimi, Sakai Miyako, Sawaguchi Shoichi

This study found uveal effusion is common in acute angle-closure glaucoma (58%) and more prevalent in chronic angle-closure (14%) than open-angle glaucoma (1.3%), correlating with shallower anterior chambers.

Sakai Hiroshi, Ishikawa Hideo, Shinzato Manabu, Nakamura Yoshimi, Sakai Miyako, Sawaguchi Shoichi

Subclinical ciliochoroidal effusion frequently occurs after prophylactic laser iridotomy, particularly with argon laser, but resolves spontaneously, suggesting a temporary, benign post-procedure effect.