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TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure.
Sappington Rebecca M, Sidorova Tatiana, Long Daniel J, Calkins David J
Invest Ophthalmol Vis SciFeb 2009171 citationsBasic Science
This study found that TRPV1 channels significantly contribute to retinal ganglion cell death and calcium influx under pressure, suggesting TRPV1 antagonism could be a therapeutic target for glaucoma.