Talla Venu

Talla Venu, Koilkonda Rajeshwari, Kinane Chaimaa, Panchal Moxa, Khuu Tamdan, Park Kevin K

A human *Nrn1*-PEC drives robust, RGC-specific AAV2 gene expression (>83% RBPMS+ cells), even in aged/injured retinas. This offers a powerful tool for targeted glaucoma and optic neuropathy gene therapies.

Talla Venu, Koilkonda Rajeshwari, Porciatti Vittorio, Chiodo Vince, Boye Sanford L, Hauswirth William W et al.

NDUFA6 gene therapy in an MS model rescued mitochondrial function, preventing significant retinal ganglion cell loss and preserving vision. This suggests a potential treatment for optic neuritis.

Talla Venu, Yang Cui, Shaw Gerry, Porciatti Vittorio, Koilkonda Rajeshwari D, Guy John

This study found elevated serum pNF-H and reduced pattern ERG indicate optic nerve damage in experimental optic neuritis, suggesting these are valuable biomarkers for assessing neurodegeneration and predicting visual outcomes in patients.