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Characterization of Ocular Morphology in Col4a3-/- Mice as a Murine Model for Alport Syndrome.
Wang Yuwei, Zhu Ruilin, Zhao Liang, Wang Fang, Zhang Yanqin, Liu Shiguang et al.
Transl Vis Sci TechnolJul 20244 citationsBasic Science
Col4a3-/- mice, a model for Alport syndrome, showed ocular structural anomalies like thinner lens capsules and retina, and abnormal basement membranes, mirroring human disease and offering a platform for studying AS mechanisms and treatments.