Yang Enzhi

Du Rong, Yang Enzhi, Ayyala Ramesh, Du Yiqin

TMSCs resist TGF-β2-induced stress better than TM cells via HGF. HGF and TMSC secretomes offer promising cell-free glaucoma therapies by enhancing TM resilience and mitigating fibrosis.

Wang Yiwen, Osakue Deborah, Yang Enzhi, Zhou Yi, Gong Haiyan, Xia Xiaobo et al.

TMSCs showed less severe and shorter ER stress response than TM cells. Protecting the PERK pathway reduced cell death, suggesting stem cell therapy with PERK activators could aid glaucoma treatment.

Du Yiqin, Yun Hongmin, Yang Enzhi, Schuman Joel S

Human trabecular meshwork stem cells (TMSCs) injected into mouse eyes homed to the TM and differentiated. This suggests TMSCs could offer a novel cell-based therapy for glaucoma.