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17 articles in GJC
Jiang Yufan, Che Yutong, Zhang Yuning, Zhu Xiaofeng, Wu Caiqing, Lin Lixia et al.
hBMMSC-derived sEVs effectively reduced trabecular meshwork fibrosis and lowered intraocular pressure in models, showing potential for glaucoma treatment.
Li Deling, Zou Bin, Hu Qinyuan, Zhang Xinyi, Zeng Weiting, Liu Liling et al.
Single-cell sequencing of mouse visual cortex after optic nerve injury revealed bilateral neuroinflammation, more pronounced contralaterally, driven by specific glial cells and upregulated genes (Ptgds, Cryab), suggesting potential therapeutic targets.
Chen Zidong, Shen Xiaoyuan, Zhang Yuning, Yang Wenxin, Ye Jiexin, Ouyang Zhiqiang et al.
Perimouse, an internet-based visual field test, reliably detected glaucoma defects, strongly correlating with HFA. Its accessibility offers potential for widespread glaucoma screening and monitoring.
Zhu Xiaofeng, Zeng Bei, Wu Caiqing, Chen Zidong, Yu Minbin, Yang Yangfan
Pirfenidone inhibited fibrosis in glaucoma cells and lowered eye pressure in mice by reducing ECM and reorganizing cell structure, suggesting a new glaucoma treatment.
Yang Yangfan, Zhang Xinyi, Chen Zidong, Wei Yifan, Ye Qiaona, Fan Yanmei et al.
This study found younger age, male gender, and thicker corneas correlated with higher baseline IOP in POAG, and thicker corneas in OHT. Peak IOP often occurred in the morning, aiding glaucoma management.
Ye Yiming, Xu Yunzhi, Yang Yangfan, Fan Yanmei, Liu Pingping, Yu Keming et al.
Topical glaucoma medications cause widespread corneal epithelial thinning. Older patients and those on multiple medications need early epithelial protection to mitigate this damage.
Xu Yunzhi, Ye Yiming, Chong Iok Tong, Chen Zidong, Xu Jiangang, Yang Yangfan et al.
This study found a new corneal indentation device (CID) accurately measures corneal stiffness, correlating with established methods, suggesting it's a promising clinical tool for glaucoma assessment.
Wen Yun, Chen Zidong, Chen Shuo, Tan Kaixin, Kong Yang, Cheng Hui et al.
Glaucoma patients showed higher contrast thresholds for vanishing optotypes in macular vision. This test better reflects retinal ganglion cell damage than standard sensitivity, potentially aiding early glaucoma detection.
Wen Yun, Chen Zidong, Zuo Chengguo, Yang Yangfan, Xu Jiangang, Kong Yang et al.
This study found high-pass visual acuity is more sensitive to glaucoma-related visual loss and better correlates with macular damage than conventional VA, suggesting its potential for monitoring glaucoma.
Zhan Zongyi, Wu Yali, Liu Zitian, Quan Yadan, Li Deling, Huang Yiru et al.
Unilateral optic nerve crush in mice reduced visual cortex dendritic spines, suggesting that glaucoma-related vision loss involves brain changes, potentially linked to reactive astrocytes and TrkB signaling.
Li Cheng, Guo Congcong, Yang Yangfan, Yu Minbin, Ge Jian, Fan Zhigang
A patient developed new optic disc pit maculopathy after glaucoma surgery, suggesting a potential link between intraocular pressure changes and this rare retinal condition.
Ye Yiming, Yang Yangfan, Fan Yanmei, Lan Min, Yu Keming, Yu Minbin
Corvis ST's biomechanically corrected IOP was higher than Goldmann IOP in glaucoma/OHT patients, influenced by corneal thickness and age, suggesting these methods are not interchangeable clinically.
Cai Xiaoxiao, Yang Yangfan, Chen Pei, Ye Yiming, Liu Xiao'an, Wu Kaili et al.
Tetramethylpyrazine (TMP) was studied in human Tenon's fibroblasts. It significantly reduced fibrosis, proliferation, and extracellular matrix accumulation, suggesting TMP could be a promising anti-scarring agent for glaucoma surgery.
Ye Yiming, Yang Yangfan, Cai Xiaoxiao, Liu Liling, Wu Kaili, Yu Minbin
Studying TM cells, researchers found down-regulating 14-3-3 zeta inhibits TGF-β1-induced contraction by affecting the RhoA pathway. This suggests a potential therapeutic target for glaucoma.
Zhong Hua, Li Jun, Li Cairui, Wei Tao, Cha Xueping, Cai Ning et al.
This study found glaucoma prevalence of 2.2% in rural Chinese Bai adults, with similar rates of POAG and PACG. PACG caused significantly more blindness, highlighting its severe impact in this population.
Zhong Hua, Sun Guoying, Lin Xianchai, Wu Kaili, Yu Minbin
This study found 0.5% pirfenidone eye drops improved bleb survival and reduced scarring in experimental glaucoma surgery, suggesting it's a safe, effective anti-scarring agent for human trabeculectomy.
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