Anderson Michael G

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension.

A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma.

Individuals with glaucoma have lower CST and CCT measurements compared with individuals without glaucoma. An increased number of glaucoma medications were associated with lower thickness measurements.

AxonDeep: Automated Optic Nerve Axon Segmentation in Mice With Deep Learning.

AxonDeep performs automated quantification and segmentation of axons from healthy-appearing nerves and those with mild to moderate degrees of damage, similar to that of experts without the variability and constraints associated with manual performance.

AxoNet 2.0: A Deep Learning-Based Tool for Morphometric Analysis of Retinal Ganglion Cell Axons.

AxoNet 2.0 provides a fast and nonsubjective tool to quantify both RGC axon counts and morphological features, thus assisting with assessing axonal damage in animal models of glaucomatous optic neuropathy.

Update on Animal Models of Exfoliation Syndrome.

One strain of mice, B6-Lyst, has several key features of human XFS, including ocular production of exfoliation-like material, and stereotypical iris abnormalities.

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

This is the first histopathological analysis of an eye from a glaucoma patient with amutation.

Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice.

Amongst outbred mice, OCT-derived measurements of GCC thickness correlate significantly to RGC somal and axon abundance.

Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness.

Our findings demonstrate a quantitative multigenic pattern of CCT inheritance in mice and identify three previously unrecognized CCT-influencing loci: Cctq4, Cctq5, and Cctq6.