Bell Katharina

Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Müller Cell Secretion.

An age-dependent decrease in CRYAB, CRYBB2, and CRYGB abundance is found going along with increased RGC loss.

Association of the CYP39A1 G204E Genetic Variant with Increased Risk of Glaucoma and Blindness in Patients with Exfoliation Syndrome.

Patients with XFS carrying the CYP39A1 G204E mutation had significantly increased risk of blindness, higher occurrence of XFG, and more severe glaucoma compared with patients with XFS without any CYP39A1 mutation.

Longitudinal variability outcomes of frontloaded visual field testing.

Frontloading VF tests on the same visit may help clinicians meet the recommendations of minimum test frequency in glaucoma and can decrease the longitudinal variability of global and pointwise sensitivity changes.

On the Feasibility of Accelerating Glaucoma Clinical Trials Using Portable Perimetry.

Home VF assessments, despite poorer reliability than current reference standard ("in-clinic") devices, would allow faster or greater detection of glaucoma progression via an increased frequency of testing, and could reduce the sample size requirements of future clinical trials.

Prediction of repeatable glaucomatous visual field defects based on cluster characteristics.

The location, size and volume of clusters of defects on an initial VF test may be predictive of subsequent repeatability. This may help distinguish eyes with a higher risk of repeatable defects.

Refining Visual Field Trend Progression Criteria in Glaucoma: Impact of Significance Thresholds and Test Frequency.

A substantial proportion of apparent progression at the established P < 0.05 threshold may be falsely positive.

Does Bevacizumab Improve Outcomes After Ahmed Glaucoma Valve Implantation for Refractory Glaucoma?: A Meta-Analysis.

Published studies investigating the role of adjunctive bevacizumab show a strong trend to improve outcomes but contain a relatively small number of participants.