James D. Brandt

Central Corneal Thickness in the Ocular Hypertension Treatment Study (OHTS).

African American subjects have thinner corneas than white subjects in the study.

Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 3 Years of Follow-up.

There was no significant difference in the rate of surgical failure between the 2 surgical procedures at 3 years.

Oral Memantine for the Treatment of Glaucoma: Design and Results of 2 Randomized, Placebo-Controlled, Phase 3 Studies.

With technologies available when the studies were conducted, daily treatment with memantine over 48 months was not shown to prevent glaucomatous progression in this patient population.

Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up.

Trabeculectomy with MMC and tube shunt surgery produced similar IOPs after 5 years of follow-up in the PTVT Study, but fewer glaucoma medications were required after trabeculectomy.

Long-term Safety and Efficacy of a Sustained-Release Bimatoprost Ocular Ring.

Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up.

A large number of surgical complications were observed in the PTVT Study, but most were transient and self-limited.

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

In this study, only one-fourth of participants in the Ocular Hypertension Treatment Study developed visual field loss in either eye over long-term follow-up.

A Comparison of Trabeculectomy Surgery Outcomes With Mitomycin-C Applied by Intra-Tenon Injection Versus Sponge.

The application of MMC by injection was similar to application by sponge in lowering IOP in patients with glaucoma and the safety of both techniques appears to be comparable.

Trabeculotomy Ab Interno With the Trab360 Device for Childhood Glaucomas.

Trab360 success resembles literature on other angle surgeries for childhood glaucomas.

Use of a Novel Microshunt in Refractory Childhood Glaucoma: Initial Experience in a Compassionate Use/Early Access Cohort.

These early data suggest that the device is safe and appears effective in patients with refractory childhood glaucoma. A prospective, multicenter pivotal trial is planned.

Combined Dexamethasone Intravitreal Implant and Glaucoma Drainage Device Placement for Uveitic Glaucoma.

In this small case series, dexamethasone intravitreal implant combined with Ahmed glaucoma drainage device appears to be an effective approach for the management of uncontrolled uveitic glaucoma.

Geographic Information System Mapping of Social Risk Factors and Patient Outcomes of Pediatric Glaucoma.

Private insurance patients had lower final IOP than Medicaid patients.

Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status.

These findings support the need for further studies to confirm the association between POAG diagnosis and a decrease in mental health score and to develop strategies to inform patients about their POAG diagnosis without producing…

Visual Field Progression in the Ocular Hypertension Treatment Study.

Some participants in OHTS had rapid rates of VF loss in one or both eyes despite being followed in a clinical study.

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

These findings support considering use of a POAG PRS threshold to identify individuals at low risk of disease onset, with those below the PRS threshold more likely to have lower conversion rates over 20 years.

Ab-Externo MicroShunt vs. Trabeculectomy in Primary Open-Angle Glaucoma: 5-Year Safety Results from a Randomized, Multicenter Study.

Both filtering procedures demonstrated favorable safety profiles over 5 years.

Childhood Glaucoma.

However, with the greatly improved visual prognosis in childhood glaucoma come unique considerations in how we care for these patients over a very long lifespan.

Glaucoma Following Cataract Surgery in Children-Finally, a Clue.

Tube Fenestration in the Tube Versus Trabeculectomy Study.

Six-Month Intraocular Pressure Reduction with a Topical Bimatoprost Ocular Insert: Results of a Phase II Randomized Controlled Study.

Clinically relevant reduction in mean IOP was observed over 6 months with a bimatoprost ocular insert and seems to be safe and well tolerated.

Human Factors and Ophthalmic Drug Packaging: Time for a Global Standard.