Mitchell Brigell
Durham Technical Community College · Independent Sector · Aerpio Pharmaceuticals (United States)
In this database
2
2020 – 2022
DB Citations
56
across indexed articles
h-index
33
OpenAlex (all works)
Total Citations
8,342
OpenAlex (all works)
2 articles in Glaucoma Journal Club
A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.
This is the first report of IOP lowering in humans with a Tie2 activator and functional demonstration of its action in remodeling SC to increase outflow facility and lower IOP in fully developed mice.
Tie2 Activation via VE-PTP Inhibition With Razuprotafib as an Adjunct to Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension.
Topical ocular razuprotafib as an adjunct to latanoprost therapy was well tolerated and significantly reduced IOP in patients with OAG/OHT.