Balwantray C. Chauhan

Evidence-based Criteria for Assessment of Visual Field Reliability.

FL have little impact on reliability in patients with established glaucoma.

Serial Changes in Lamina Cribrosa Depth and Neuroretinal Parameters in Glaucoma: Impact of Choroidal Thickness.

Lamina cribrosa depth should be measured from an anterior sclera reference plane to reduce the influence of choroidal thickness changes.

Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.

Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera.

Improving the Feasibility of Glaucoma Clinical Trials Using Trend-Based Visual Field Progression Endpoints.

The feasibility of future glaucoma clinical trials can be substantially improved by evaluating differences in the rate of visual field change between groups.

Value of 10-2 Visual Field Testing in Glaucoma Patients with Early 24-2 Visual Field Loss.

In this study of glaucoma patients with early damage with the 24-2 test, there was little evidence that adding the 10-2 test revealed additional undetected defects in the central visual field.

Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.

In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness.

Age and intraocular pressure in murine experimental glaucoma.

We also evaluate how age modulates the impact of elevated IOP on RGC somal and axonal density in histological analysis as well the density of melanopsin RGCs.

Visibility of Optic Nerve Head Structures With Spectral-domain and Swept-source Optical Coherence Tomography.

SD-OCT and SS-OCT had comparable detection rates of deep ONH structures; however, a larger area of ASLC was visible with SS-OCT.

Discrepancy in Loss of Macular Perfusion Density and Ganglion Cell Layer Thickness in Early Glaucoma.

Less than one-third of patients with early glaucoma had more loss of perfusion compared with conventional structural loss in the macula.

OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.

Our data suggest that pNC-SB is increased and pNC-CT is decreased in highly myopic eyes and that these phenomena are greatest in the inferior sectors.

Factors Predicting a Greater Likelihood of Poor Visual Field Reliability in Glaucoma Patients and Suspects.

FPs, test duration, and FNs are the primary measures predicting if a VF is likely to be reliable, although tests with normal reliability measures may still be unreliable.

Impact of Glaucoma Severity on Rates of Neuroretinal Rim, Retinal Nerve Fiber Layer, and Macular Ganglion Cell Layer Thickness Change.

The rates of MRW, RNFL, and GCL thickness change were not significantly influenced by glaucoma severity at baseline; however, GCL thickness was able to statistically contrast the rate of change between healthy subjects and glaucoma…

Comparing Five Criteria for Evaluating Glaucomatous Visual Fields.

No criteria had uniformly superior performance. Selection of criteria should consider the degree of damage anticipated and the desire for either higher sensitivity or specificity.

Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria.

Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.

Longitudinal In Vivo Changes in Retinal Ganglion Cell Dendritic Morphology After Acute and Chronic Optic Nerve Injury.

Rapid dendritic changes occurred after ONT, while changes in EG were slower and associated with level of IOP increase. The earliest alterations were loss of inner neurites without change in dendritic field.

Rates of Visual Field Change in Patients With Glaucoma and Healthy Individuals: Findings From a Median 25-Year Follow-up.

The results of this cohort study suggest that over a median follow-up of more than 25 years, the rate of visual field change in patients receiving treatment for glaucoma was comparable to that of healthy individuals.

Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma.

High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH.

OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.

ENC region tissue remodeling that includes the scleral flange is enhanced in Hi-Myo compared to Non-Hi-Myo-Healthy eyes.

Influence of Bruch's Membrane Opening Area in Diagnosing Glaucoma With Neuroretinal Parameters From Optical Coherence Tomography.

RNFLT sensitivity was higher in eyes with larger BMOA; however, age and visual field damage may influence that association. MRW diagnostic accuracy was not dependent on BMOA.

Nomograms for Converting Perimetric Sensitivity From Full Threshold and SITA Fast to SITA Standard in Patients With Glaucoma and Healthy Subjects.

Nomograms to convert FT and SF tests to SS tests yield accuracies that are negligibly different from test-retest differences with SS.

Peripapillary Retinal Segmentation in OCT Angiography.

Progressive Changes in the Neuroretinal Rim and Retinal Nerve Fiber Layer in Glaucoma: Impact of Baseline Values and Floor Effects.

Significant MRW and RNFLT changes were detected at all levels of baseline damage.

Global Glaucoma Prevalence: Burden and Projection to 2060.

There is a significant, previously underestimated, increase in OAG burden globally, driven by the rising prevalence of myopia.

Rates of Visual Field Change in Patients With Glaucoma and Healthy Individuals-Findings From a Median 25-Year Follow-up-Reply.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed.

Crowd-Sourced Glaucoma Study. Definition of Glaucoma for Research by a Large Group of Global Expert Evaluators.

The CSGS criteria represent parameter-defined consensus-based definition of glaucoma for clinical research.

The usefulness of routine photography in a myopic patient treated for glaucoma: 36-year follow-up.

Understanding the Increasing Role of Optical Coherence Tomography in Glaucoma Diagnostics and Disease Progression.

A Comparative Study of the Handheld IC200 and Slit Lamp-mounted ST500 Rebound Tonometers with Goldmann Applanation Tonometry.

The ST500 shows good agreement with GAT over a large range of IOP and significantly higher repeatability compared to the IC200 and GAT, suggesting it may be advantageous in clinical settings where topical anesthesia or skilled staff are unavailable.

Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma.

A decrease in GCL thickness precedes a measurable decrease in macular PD. Early glaucomatous progression is more frequently detectable with changes in GCL thickness compared to macular PD.

Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements.

Using pixel-based methods, the diagnostic accuracy of NFL and GCL exceeded that of IPL and TR.

Impact of ageing on progressive thinning of the retinal nerve fibre layer in glaucoma.

Normal aging contributes about half of the retinal nerve fiber layer thinning observed in treated glaucoma patients, with glaucoma itself causing additional significant thinning. This highlights the importance of distinguishing age-related changes from disease progression.

Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging.

Perfusion density measurements are subject to increasing experience of either the operator or participant, or a combination of both. These findings have implications for the interpretation of longitudinal measurements with OCT-A.

Analysis of deep optic nerve head structures with spectral domain and swept-source optical coherence tomography.

Overall, both SS-OCT and SD-OCT showed statistically equivalent visualisation of ONH structures, however, SS-OCT tended to have higher visualisation rates.

Optic Disc Hemorrhages and Laminar Disinsertions in Glaucoma.

Laminar disinsertions occurred twice as frequently in eyes with ODHs; however, in individual patients, the spatial concordance between ODHs and laminar disinsertions was poor.

Beta and Gamma Peripapillary Atrophy in Myopic Eyes With and Without Glaucoma.

Subclassifying PPA with OCT into beta and gamma zones reveals association with different covariates, but does not enhance the diagnostic performance for glaucoma in a population of predominantly Caucasians myopic subjects.

Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes.

Bruch's membrane opening MRW is more sensitive than DM-RA and similar to RNFL thickness for the identification of glaucoma in myopic eyes and offers a valuable diagnostic tool for patients with glaucoma with myopic optic…

Neuroretinal Rim Area Change in Glaucoma Patients With Visual Field Progression Endpoints and Intraocular Pressure Reduction. The Canadian Glaucoma Study: 4.

Patients with a VF endpoint had a median rim area rate that was nearly 3 times worse than those without an endpoint.

Diagnostic Accuracy of Glaucoma With Sector-Based and a New Total Profile-Based Analysis of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness.

The diagnostic accuracy of sectoral analysis was equivalent to total analysis. These results indicate that BMO-MRW and RNFLT defects were wide and deep enough for detection by conventional sectoral analysis.

Importance of Normal Aging in Estimating the Rate of Glaucomatous Neuroretinal Rim and Retinal Nerve Fiber Layer Loss.

Age-related loss of neuroretinal parameters may explain a large proportion of the deterioration observed in treated patients with glaucoma and should be carefully considered in estimating rates of change.

Bruch's Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study.

There was significant age-related loss of BMO-MRW in healthy subjects and notable differences between BMO-MRW and RNFLT in their relationship with age and between each other.

Imaging retinal ganglion cells: enabling experimental technology for clinical application.

This type of experimental work is important in progressing towards clinically applicable methods for monitoring loss of RGCs in glaucoma and other optic neuropathies.