Chen Li Jia

Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma.

This meta-analysis confirmed the association of rs10483727 and rs33912345 in SIX1-SIX6 with POAG.

Association of the CAV1-CAV2 locus with normal-tension glaucoma in Chinese and Japanese.

In this study, we confirmed the association of rs4236601 at the CAV1-CAV2 locus with NTG in Chinese.

Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.

These findings enrich the allelic spectrum of ABCC5 in PACG.

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study.

Lower FVC, FEV1, FEV1/FVC, and impaired lung function are potential biomarkers for glaucoma risk. These findings may facilitate clinical strategies for glaucoma management, particularly for individuals with impaired lung function.

Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis.

This study revealed the genetic complexity of primary angle-closure disease, involving common SNVs and rare coding variants in more than 30 genes or loci, with ethnic and phenotypic diversities.

Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study.

This study suggested that LTL is not a major biomarker for incident glaucoma in the UK Biobank population. Further studies in different populations are warranted.

Large-Scaled Proteomics Analysis for Glaucoma: Integrated Genetics, Multi-Omics, UK Biobank and Therapeutic Analysis.

Our findings provide new insights into the proteomic basis of glaucoma and highlight promising opportunities for developing targeted therapies.

Association of polymorphisms in 17 loci with primary open-angle glaucoma in Chinese and Japanese.

This study confirmsrs938604,rs62283813,rs9913911 andrs4414666 as HTG-specific loci in Chinese and Japanese populations. These findings provide new insights into the genetic architecture of POAG, highlighting distinct molecular mechanisms between HTG and NTG subtypes.

Ocular and Systemic Risk Factors and Biomarkers for Primary Glaucoma: An Umbrella Review of Systematic Reviews With Meta-Analyses.

This umbrella review highlights the evidence hierarchy of various ocular and systemic risk factors and biomarkers associated with glaucoma. Further high-quality studies are essential to strengthen the evidence base.

Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression.

This study demonstrated a role of LOXL1 in PACG and a sex-specific effect of ABCA1 in the Hong Kong Chinese population while suggesting a potential role of VAV3 in PACG progression, which has yet to…

Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis.

In this study, we confirmed multiple polymorphisms in 8 genes/loci as genetic biomarkers for PACD, among which 3 were identified in a genome-wide association study (COL11A1, PLEKHA7, and PCMTD1-ST18), and 5 were identified in candidate gene…