Carol Y. Cheung

Retinal Nerve Fiber Layer Thickness in a Multiethnic Normal Asian Population: The Singapore Epidemiology of Eye Diseases Study.

Average and regional RNFL thicknesses were significantly thinner in Indian eyes compared with Chinese and Malay eyes.

A 3D Deep Learning System for Detecting Referable Glaucoma Using Full OCT Macular Cube Scans.

A 3D deep learning algorithm trained on macular OCT volumes without retinal disease to detect referable glaucoma performs better with retinal segmentation preprocessing and performs reasonably well across all levels of myopia.

The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study.

We quantified the effect of unreliable responses on the MD and PSD in SAP.

Deep Learning for Glaucoma Detection and Identification of Novel Diagnostic Areas in Diverse Real-World Datasets.

A 3D convolutional neural network (CNN) trained on SD-OCT ONH cubes can distinguish glaucoma from normal cases in diverse datasets obtained from four different countries.

Profiles of Ganglion Cell-Inner Plexiform Layer Thickness in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study.

GCIPL thickness profiles were significantly thinner in Indians compared with Chinese and Malays.

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study.

VD in DCP reduced significantly more quickly in POAG eyes with high myopia over time. Density in the DCP reduced more quickly when baseline VD was low.

Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians: Pooled Analysis from the Asian Eye Epidemiology Consortium.

In this large pooled analysis of Asian population studies, Indian and Japanese eyes were observed to have thinner RNFL profiles. These findings suggest the need for an ethnic-specific normative database to improve glaucoma detection.

Characterization of macular choroid in normal-tension glaucoma: a swept-source optical coherence tomography study.

We found significant alterations in macular choroidal vascularity (reduced CVI and thinner layer) in NTG patients.

Factors Associated With Long-term Intraocular Pressure Fluctuation in Primary Angle Closure Disease: The CUHK PACG Longitudinal (CUPAL) Study.

PACG eyes have greater IOP fluctuation than PAC/PACS eyes. Certain demographic, ocular, and systemic factors are associated with IOP fluctuation in PACD eyes.

Optical coherence tomography angiography metrics predict normal tension glaucoma progression.

High Myopia Normative Database of Peripapillary Retinal Nerve Fiber Layer Thickness to Detect Myopic Glaucoma in a Chinese Population.

The HM-specific normative database is more capable of detecting HMG eyes than the SS OCT built-in database, which may be an effective tool for differential diagnosis between HMG and HM.

Risk of Normal Tension Glaucoma Progression From Automated Baseline Retinal-Vessel Caliber Analysis: A Prospective Cohort Study.

In this study, each SD decrease in the baseline CRAE or CRVE was associated with a more than 30% increase in the risk of progressive RNFL thinning and a more than 90% increase in the risk of VF deterioration during the follow-up period.

Intraocular Pressure Control Predicts Retinal Nerve Fiber Layer Thinning in Primary Angle Closure Disease: The CUPAL Study.

In treated PACD eyes, large IOP fluctuation is an independent predictor for subsequent progressive RNFL thinning in addition to high mean IOP during follow-up.

Association of Ultra-Short-Term Intraocular Pressure Fluctuation With Disease Progression in Primary Angle Closure Glaucoma: The CUPAL Study.

Between RNFL 'progressive' and 'stable' PACG eyes, significant differences in ultra-short-term IOP fluctuation at the 1-hour period after falling asleep were identified.

Global Glaucoma Prevalence: Burden and Projection to 2060.

There is a significant, previously underestimated, increase in OAG burden globally, driven by the rising prevalence of myopia.

Re: Xiong et al.: Multimodal machine learning using visual fields and peripapillary circular OCT scans in detection of glaucomatous optic neuropathy (Ophthalmology. 2022;129:171-180).

Ocular and Systemic Risk Factors and Biomarkers for Primary Glaucoma: An Umbrella Review of Systematic Reviews With Meta-Analyses.

This umbrella review highlights the evidence hierarchy of various ocular and systemic risk factors and biomarkers associated with glaucoma. Further high-quality studies are essential to strengthen the evidence base.

Risk Factors for Visual Field Progression in Primary Angle Closure Disease Over 10 Years: The CUPAL Study.

Our findings underscore the importance of monitoring IOP fluctuation in PACG eyes and initial VFI slope in PACD eyes, supporting the implementation of tailored management strategies based on disease severity and refractive status.

Developing a privacy-preserving deep learning model for glaucoma detection: a multicentre study with federated learning.

The 3D FL model could leverage all the datasets and achieve generalisable performance, without data exchange across centres.

Determinants of pupil diameters and pupil dynamics in an adult Chinese population.

Among normal eyes in an adult Chinese population, SPC was associated with larger baseline PD.

Structural Differences in the Optic Nerve Head of Glaucoma Patients With and Without Disc Hemorrhages.

Eyes with DH consistently displayed both structural features of more advanced glaucoma confirmed simultaneously on planimetry and SD-OCT, with concurrent VF deterioration.

Relationship Between Peripapillary Choroid and Retinal Nerve Fiber Layer Thickness in a Population-Based Sample of Nonglaucomatous Eyes.

Thinner peripapillary choroid was independently associated with thinner RNFL globally and in the inferior and superior regions. This structure-structure relationship may need further exploration in glaucomatous eyes prior to its application in clinical settings.

Retinal vascular caliber between eyes with asymmetric glaucoma.

In glaucoma with asymmetric severity between fellow eyes, retinal vascular caliber is less in the eye with more severe disease.