Chong Rachel S

Mendelian Randomization Implicates Bidirectional Association between Myopia and Primary Open-Angle Glaucoma or Intraocular Pressure.

A strong bidirectional genetic causal link exists between myopia and POAG that is mediated mainly by IOP.

Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma.

DL networks trained with synthetic OCT images for glaucoma detection were comparable with networks trained with real images.

Association of Antihypertensive Medication with Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness.

Use of 2 or more antihypertensive medications, ACEI, and diuretics were associated with a loss of structural markers of retinal ganglion cell health in a multiethnic Asian population.

Experimental models of glaucoma filtration surgery.

However, this research needs to be interpreted in the light of the specific study design, animal model and methods used.

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head.

Our study revealed that eyes with HMG experienced significantly greater strains under IOP compared to eyes with HM. Furthermore, eyes with PM + S had the highest strains on the ONH of all groups.

High Myopia Normative Database of Peripapillary Retinal Nerve Fiber Layer Thickness to Detect Myopic Glaucoma in a Chinese Population.

The HM-specific normative database is more capable of detecting HMG eyes than the SS OCT built-in database, which may be an effective tool for differential diagnosis between HMG and HM.

A Minimally Invasive Experimental Model of Acute Ocular Hypertension with Acute Angle Closure Characteristics.

Our minimally invasive model resulted in acute OHT with characteristics of AAC in the absence of non-OHT-related neuroinflammatory changes arising from ocular injury alone.

Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.

Higher IOP and longer AXL are associated with distinct structural changes of the ONH in highly myopic eyes, particularly involving the lamina cribrosa.

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.

Our findings indicate that the macula in HMG, PM, and PM+S eyes showed greater curvature changes under IOP elevation compared to HM and emmetropic eyes.

Atypical presentation of ocular decompression retinopathy following trabeculectomy.

Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension.

Platelet-derived growth factor increased microglial and monocyte-derived macrophage populations in the eye and protected intraretinal synapses from degeneration in our experimental glaucoma model.