Cole Brian S

The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.

In sum, the POAAGG study population is very admixed, with a higher degree of African ancestry associated with an increased POAG risk.

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.

One in 4 individuals with the MYOC p.Gln368Ter mutation demonstrated evidence of glaucoma, a substantially higher penetrance than previously estimated, with 69% of cases undetected.