Jessica N. Cooke Bailey

Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.

We have found that the APOE ε4 allele is associated with a reduced risk of POAG.

Myocilin Mutations in Patients With Normal-Tension Glaucoma.

In cohorts 1 and 2, the p.Gln368Ter mutation in MYOC was found in patients with IOPs that were 21 mm Hg or lower (NTG), although at a frequency that is lower than previously detected in patients with higher IOP.

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.

These analyses suggest that there is limited genetic correlation between diabetes- and glaucoma-related traits.

Glaucoma Genetic Risk Scores in the Million Veteran Program.

Varied performance of the GRS for POAG risk stratification and documented IGS association in EUR and AFR Veterans highlights (1) the complex risk architecture of POAG, (2) the importance of diverse representation in genomics studies…

Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes.

Patients with POAG with higher TXNRD2 and ME3 GRSs showed higher treated IOP and a greater prevalence of paracentral field loss.

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

In this cross-sectional study, despite some improvements in OR-based risk stratification using the Gharahkhani PRSs, Han PRSs, and Craig PRSs, consistently lower improvements in AUROC and R2 for African-ancestry compared with European-ancestry groups highlight the…

Progress, Not Perfection: Intraocular Pressure Genetic Risk Score Stratifies Clinically Relevant Primary Open-Angle Glaucoma Outcomes.

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses.

We present an effective approach for assessing the contributions of mitochondrial genetic variation to open-angle glaucoma.