Jonathan G. Crowston

High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma: Metabolomics and Mendelian Randomization Analyses.

Overall, these results suggest that the relationship between HDL3 cholesterol and POAG might be causal and specific, and that dysregulation of cholesterol transport may play a role in the pathogenesis of POAG.

Time-Frequency Analysis of ERG With Discrete Wavelet Transform and Matching Pursuits for Glaucoma.

Novel time-frequency features extracted from the photopic ERG substantially added to the prediction of glaucoma severity compared to using the time-domain amplitude markers alone.

Longitudinal variability outcomes of frontloaded visual field testing.

Frontloading VF tests on the same visit may help clinicians meet the recommendations of minimum test frequency in glaucoma and can decrease the longitudinal variability of global and pointwise sensitivity changes.

Association Between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects With Intraocular Pressure Reduction After Trabeculectomy.

Characteristics derived from the baseline structure-function relationship were found to be strongly associated with postoperative VF outcomes. These findings suggest that the structure-function relationship could potentially have a role in predicting VF progression after trabeculectomy.

On the Feasibility of Accelerating Glaucoma Clinical Trials Using Portable Perimetry.

Home VF assessments, despite poorer reliability than current reference standard ("in-clinic") devices, would allow faster or greater detection of glaucoma progression via an increased frequency of testing, and could reduce the sample size requirements of future clinical trials.

Prediction of repeatable glaucomatous visual field defects based on cluster characteristics.

The location, size and volume of clusters of defects on an initial VF test may be predictive of subsequent repeatability. This may help distinguish eyes with a higher risk of repeatable defects.

Refining Visual Field Trend Progression Criteria in Glaucoma: Impact of Significance Thresholds and Test Frequency.

A substantial proportion of apparent progression at the established P < 0.05 threshold may be falsely positive.

Does Bevacizumab Improve Outcomes After Ahmed Glaucoma Valve Implantation for Refractory Glaucoma?: A Meta-Analysis.

Published studies investigating the role of adjunctive bevacizumab show a strong trend to improve outcomes but contain a relatively small number of participants.

Impact of age-related macular degeneration in patients with glaucoma: understanding the patients' perspective.

Vision-related activity limitation and preference-based status are negatively impacted by severe glaucoma and age-related macular degeneration. Patients with both conditions perceive increased difficulty walking safely compared with patients with glaucoma alone.