Deng Xizhi

Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition.

Based on the results, NR effectively enhances intracellular levels of NAD+, thereby mitigating abnormal ECM deposition and TM dysfunction in GIG by attenuating mitochondrial damage induced by GCs.

Maraviroc Prevents Optic Nerve Injury-Induced Retinal Ganglion Cell Apoptosis by Modulating the CCL5/CCR5/CTSS Axis.

Microglial activation in glaucoma upregulates CCL5, triggering CCR5-mediated RGC apoptosis via CTSS downregulation. Maraviroc effectively reduces RGC death and optic nerve damage, offering a promising neuroprotective strategy for treatment of optic nerve injury.