Graham Stuart

Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances.

This review summarises the existing knowledge that informs our understanding of the impact of AD on the retina and highlights some of the gaps that need to be addressed.

Contribution of Mutations in Known Mendelian Glaucoma Genes to Advanced Early-Onset Primary Open-Angle Glaucoma.

Rare, potentially disease-causing variants in Mendelian POAG genes that showed enrichment in our dataset were found in 22.9% of advanced early-onset POAG cases.

Determination of retinal nerve fibre layer and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems: The PROGRESSA study.

Despite baseline thickness differences, overall Cirrus and Spectralis provided similar rates of RNFL and GCL/IPL progression in early glaucoma and can be considered comparable, though not interchangeable, in clinical practice.

Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma.

High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH.

Quantification of localised vascular wedge-shaped defects in glaucoma.

Vascular wedge defects are present at all POAG stages even before functional change and are strongly concordant with focal RNFL loss.

Optimizing the Detection of Preperimetric Glaucoma by Combining Structural and Functional Tests.

The LLA mfVEP test identified approximately 50.6% eyes with preperimetric glaucoma, which was significantly higher than other perimetric methods, and similar to HRT.